Visualization of light propagation in visible Chinese human head for functional near-infrared spectroscopy

Journal of Biomedical Optics
Ting LiQingming Luo


Using the visible Chinese human data set, which faithfully represents human anatomy, we visualize the light propagation in the head in detail based on Monte Carlo simulation. The simulation is verified to agree with published experimental results in terms of a differential path-length factor. The spatial sensitivity profile turns out to seem like a fat tropical fish with strong distortion along the folding cerebral surface. The sensitive brain region covers the gray matter and extends to the superficial white matter, leading to a large penetration depth (>3 cm). Finally, the optimal source-detector separation is suggested to be narrowed down to 3-3.5 cm, while the sensitivity of the detected signal to brain activation reaches the peak of 8%. These results indicate that the cerebral cortex folding geometry actually has substantial effects on light propagation, which should be necessarily considered for applications of functional near-infrared spectroscopy.


Feb 1, 1994·Medical Physics·I G ZubalP B Hoffer
Dec 1, 1995·Physics in Medicine and Biology·Eiji OkadaD T Delpy
Nov 5, 1997·Trends in Neurosciences·A Villringer, B Chance
Jan 27, 2004·NeuroImage·M A Franceschini, David A Boas
Dec 11, 2007·Physics in Medicine and Biology·Guozhi ZhangQingming Luo
Jan 1, 2008·Journal of Biomedical Optics·Yoko Hoshi


Apr 19, 2012·Biomedical Engineering Online·Ching-Cheng ChuangChia-Wei Sun
Oct 2, 2012·The Review of Scientific Instruments·Zhongxing ZhangQingming Luo
Nov 1, 2018·Journal of Biophotonics·Boan PanTing Li
Mar 16, 2012·Optics Express·Jin Wook JungJong Chul Ye
Mar 18, 2015·Journal of Biomedical Optics·Albert E CerussiBrian Wong
Jun 2, 2017·Frontiers in Human Neuroscience·Joana B BalardinJoão R Sato
Mar 6, 2019·Journal of Korean Medical Science·Beom Sun ChungJin Seo Park
Mar 7, 2019·Journal of Healthcare Engineering·Zhenglun KongShengpu Xu
Sep 22, 2018·Neurophotonics·Sabrina BrigadoiRobert J Cooper

Related Concepts

Insula of Reil
In Silico
Monte Carlo Method
Spectroscopy, Near-Infrared
Visible Korean Human Project
Cerebral Cortex
Gray Matter

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