PMID: 9170619Apr 1, 1997Paper

Visualization of lung cancer with 99Tcm-tetrofosmin imaging: a comparison with 201T1

Nuclear Medicine Communications
H TakekawaY Kawakami

Abstract

We evaluated the usefulness of 99Tcm-tetrofosmin imaging in lung cancer. The study sample comprised 46 patients with lung cancer. Single photon emission tomography was conducted after the intravenous injection of 740 MBq 99Tcm-tetrofosmin and 111 MBq 201T1-chloride. We obtained an uptake ratio (counts per pixel in the lesion/counts per pixel in contralateral normal lung) for each scan to evaluate the degree of uptake in the tumour. Our results demonstrate that 89.1% of the primary lung cancers were visualized by 99Tcm-tetrofosmin and 95.7% by 201T1. The difference between the 201T1 uptake ratio and the 99Tcm-tetrofosmin uptake ratio was significantly greater in squamous cell carcinomas than small cell carcinomas (P < 0.01) and tended to be greater in squamous cell carcinomas than adenocarcinomas (P = 0.093). This study has indicated that 99Tcm-tetrofosmin, like 201T1, is a highly effective agent in the delineation of lung cancer. The difference between the 99Tcm-tetrofosmin and 201T1 uptake ratios might provide further information regarding the histological type of lung cancer.

Citations

Mar 29, 2002·Cancer·Gianfranco BuccheriAntonella Francini
Oct 7, 2000·Annals of Nuclear Medicine·T HashimotoM Goto
Jun 4, 1999·Annals of Nuclear Medicine·H TakekawaY Kawakami
Dec 5, 1998·Annals of Nuclear Medicine·T TakayamaN Tonami
May 16, 2001·Clinical Nuclear Medicine·T HashimotoM Fujioka
Aug 31, 2000·Journal of Computer Assisted Tomography·M TatsumiT Nishimura
Sep 28, 2002·Clinical Nuclear Medicine·Benjamin Franc, Michael Goris

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