Visualization of Lung Inflammation to Pulmonary Fibrosis via Peroxynitrite Fluctuation

Analytical Chemistry
Zixuan ZhanYi Lv

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease with short survival time. However, owing to the unknown etiology and the lack of sensitive and noninvasive methods, the diagnosis of IPF in early stage is still full of chal-lenges. Since the levels of oxidative stress in mitochondria is relevant to pulmonary fibrosis, we herein present a simultane-ous NIR-Ia window and ratiometic fluorescent probe rTPONOO-1 with two-photon and mitochondria targeting abilities to explore the potential biological roles of peroxynitrite (ONOO-) in different states of lung slices from healthy to lung inflam-mation and pulmonary fibrosis, and there is a good linear relationship between ratiometric fluorescence changes and the rate of pulmonary fibrosis from H&E and Masson staining. In addition, the therapeutic efficacy of aminoguanidine hemi-sulfate salt (AG) was also investigated. Thus, rTPONOO-1 has great potential in quickly predicting the progression of pul-monary fibrosis in early stage and improving effective treatment.

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