Visualization of lymphatic vascular invasion in breast cancer by multiphoton microscopy.

Lasers in Medical Science
Wenjiao RenLianhuang Li

Abstract

Lymphatic vascular invasion (LVI) is regarded as one of the independent factors which affect the prognosis of breast cancer. Once LVI is formed, it indicates the tumor has metastasized or has the possibility of metastasis. In this work, multiphoton microscopy (MPM), which relies on the two-photon excited fluorescence (TPEF) and second harmonic generation (SHG), was applied to identify the typical morphology of LVI and also visualize the histological features of LVI. Furthermore, the pixel density of collagen fibers was extracted as a quantitative parameter to differentiate LVI from the ductal carcinoma in situ (DCIS). By comparing with the corresponding H&E-stained images, it was confirmed that MPM can be used as an auxiliary tool for pathologists to diagnose LVI, and has a possibility for the application in clinical examination.

References

Apr 9, 2004·The New England Journal of Medicine·Harold J BursteinCarolyn M Kaelin
Sep 20, 2005·Breast Cancer Research : BCR·Giske UrsinAnna H Wu
May 4, 2006·British Journal of Cancer·G G Van den EyndenE A Van Marck
Dec 28, 2006·BMC Medicine·Paolo P ProvenzanoPatricia J Keely
Jan 9, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Angel Arnaout-AlkarainAlexander N Marks
Apr 30, 2008·BMC Medicine·Paolo P ProvenzanoPatricia J Keely
Oct 12, 2010·Breast Cancer Research and Treatment·Jo Anne ZujewskiJennifer L Stevens
May 25, 2011·Mutation Research·Franziska van ZijlWolfgang Mikulits
May 11, 2012·Future Medicinal Chemistry·Victoria Vinader, Kamyar Afarinkia
Apr 26, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rabab A A MohammedIan O Ellis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

The Veterinary Record
A C Talbot
The Veterinary Record
R N W Ellis
The Veterinary Record
N Paull
Breast Cancer : the Journal of the Japanese Breast Cancer Society
Masahiro ItoNoriaki Ohuchi
© 2021 Meta ULC. All rights reserved