Visualization of serotonin effects on renal vessels of rats

Kidney International
K EndlichM Steinhausen

Abstract

We studied the effects of serotonin (5-hydroxytryptamine, 5-HT) on glomerular blood flow (GBF) and on renal vessel diameters in the hydronephrotic kidney and in vascular casts of normal kidneys of rats. 5-HT (60 min after local application of 10(-8) mol.liter-1) constricted the arcuate arteries (-10 +/- 2% to -14 +/- 2%, mean +/- SEM), dilated the interlobular arteries (+13 +/- 2%) and afferent arterioles (+17 +/- 3%), and decreased GBF (-44 +/- 5%). In contrast to normal autoregulation, reduction of renal perfusion pressure after local application of 5-HT from 118 +/- 3 mm Hg by 10 and 20 mm Hg reduced GBF by 12 +/- 2% and 23 +/- 3%, respectively. The 5-HT2 antagonist, ritanserin (60 min after local application of 10(-6) mol.liter-1), dilated all preglomerular vessels and increased GBF. In the presence of ritanserin, 5-HT lost nearly all vascular effects. During infusion of 5-HT (5 micrograms.min-1 i.v. for 20 min) vascular reactions were similar to those under local application. After cyclooxygenase inhibition with indomethacin, infusion of 5-HT failed to constrict the arcuate arteries whereas vasodilation of the small preglomerular vessels remained unaffected. Analyzing vascular casts of normal kidneys we observed considerab...Continue Reading

References

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Citations

Sep 15, 1998·Kidney International. Supplement·M VerbekeN H Lameire
Jun 9, 2000·Kidney International·N EndlichJ J Helwig
May 1, 1994·European Journal of Clinical Investigation·K SchlottmannM Steinhausen
Apr 9, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·N H Lameire
Apr 10, 2015·Clinical and Experimental Pharmacology & Physiology·José-Ángel García-PedrazaAsunción Morán
Dec 16, 2004·American Journal of Physiology. Renal Physiology·Frank H HansenBjarne M Iversen
Dec 7, 2006·American Journal of Physiology. Renal Physiology·William F van RodijnenGeert-Jan Tangelder
Aug 19, 2014·World Journal of Clinical Cases·Vithika SivabalasundaramDavid Cherney
Jun 6, 2006·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Lee H GoldsteinMatitiahu Berkovitch

Related Concepts

Metazoa
Blood Vessel
Hydronephrosis
Osmosin
Kidney
Receptors, Tryptamine
Renal Blood Flow
Hydroxytryptamine
Vascular Constriction (Function)
Ritanserin Tartrate

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