Visualization of the cortical dopamine transporter in type 1 and 2 alcoholics with human whole hemisphere autoradiography

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Erkki TupalaJari Tiihonen

Abstract

We measured cortical dopamine transporter (DAT) in Cloninger type 1 and 2 alcoholics by using [(125)I]PE2I as a radioligand in human postmortem whole hemispheric autoradiography, and evaluated the putative correlations of DAT between cortical areas and nucleus accumbens. There was a low, but distinct cortical binding in the cryosections. The mean binding was generally higher in both groups of alcoholics compared to controls, and the results reached statistical significance with a large effect size (1.25) in the temporal cortex of type 2 alcoholics. This is surprising, because several studies have reported lower DAT densities in the striatum among alcoholics compared to controls. Moreover, the density of DAT had a statistically significant positive correlation between temporal cortex and nucleus accumbens in controls, whereas among type 2 alcoholics the correlation was statistically significantly negative, which may suggest some pathology relating to the antisocial behaviour of these alcoholics.

References

Nov 4, 1988·Science·G F Koob, F E Bloom
Jul 15, 1986·European Journal of Pharmacology·N ZelnikJ E Kleinman
Aug 1, 1981·Archives of General Psychiatry·C R CloningerS Sigvardsson
Dec 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·H HallL Farde
Aug 1, 1994·Annals of Neurology·N D VolkowA P Wolf
Oct 1, 1993·Neuroendocrinology·B Meister, R Elde
Dec 1, 1996·Alcoholism, Clinical and Experimental Research·N D VolkowK Piscani
Oct 6, 1997·Science·G F Koob, M Le Moal
Jan 27, 1998·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·C BowdenR W Horton
Apr 20, 1999·Molecular Psychiatry·T P LaineM Hillbom

❮ Previous
Next ❯

Citations

May 15, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kelly P CosgroveJulie K Staley
Apr 30, 2011·Neuroscience and Biobehavioral Reviews·Zsofia NemodaMaria Sasvari-Szekely
Oct 2, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Stacy A Castner, Graham V Williams
May 17, 2008·CNS Neuroscience & Therapeutics·Patrick EmondSylvie Chalon
Feb 20, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Laurent KarilaEric Artiges
Oct 4, 2011·Neurobiology of Disease·Luisa RochaAnna Borsodi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.