Visualizing chromosome structure/organization

Annual Review of Plant Biology
Eric LamKoichi Watanabe

Abstract

With the rapid development of sequencing technologies in the past decade, many eukaryotic genomes have been resolved at the primary sequence level. However, organization of the genome within nuclei and the principles that govern such properties remain largely unclear. Optimization of fluorescence probe-based hybridization technologies combined with new advances in the instrumentation for microscopy has steadily yielded more structural information on chromosome organization in eukaryote model systems. These studies provide static snapshots of the detailed organization of chromatin. More recently, the successful application of a chromatin tagging strategy utilizing auto fluorescent fusion proteins opened a new era of chromatin studies in which the dynamic organization of the genome can be tracked in near real time. This review focuses on these new approaches to studying chromatin organization and dynamics in plants, and on future prospects in unraveling the basic principle of chromosome organization.

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Dec 21, 2005·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Fang-I KaoMei-Chu Chung
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Methods Mentioned

BETA
Fluorescence
fluorescence microscopy
ubiquitination
GTPase
electron microscopy
transgenic
Confocal Microscopy
fluorescence photobleaching
imaging techniques

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