PMID: 8942391Nov 1, 1996Paper

Visualizing signal transduction: receptors, G-proteins, and adenylate cyclases

Clinical Science
C W DessauerA G Gilman

Abstract

1. The first glimpses of heterotrimeric G-proteins came with the discoveries of the ubiquitous adenylate cyclase activator, Gs, and the specialized retinal cGMP phosphodiesterase activator, Gi or transducin. The model that evolved for regulation of adenylate cyclase activity by G-proteins soon proved to be a general paradigm for a large number of signalling pathways. Although many different G-proteins interact with a diverse array of receptors and effectors, each is composed of a guaninenucleotide-binding alpha-subunit and a tightly associated complex of a beta- and a gamma-subunit. 2. Receptors catalyse the activation of G-proteins by promoting exchange of GDP for GTP, while G-proteins catalyse their own deactivation as a result of their intrinsic GTPase activity. Crystallographic analysis has described several of the various conformational states that G-proteins undergo as they are activated and deactivated and has provided great insight into the kinetic models of G-protein-mediated signal transduction. 3. The regulation of adenylate cyclase has proven to be intriguing and complex. Gsx activates all forms of mammalian adenylate cyclase; other G-proteins (Gi, Go and Gz) inhibit certain isoforms of the enzyme. The discovery of ...Continue Reading

Citations

Oct 13, 2006·Cell Calcium·Kirill KiselyovShmuel Muallem
Jan 13, 2015·British Journal of Pharmacology·E V Gurevich, V V Gurevich
Jan 30, 2004·Annual Review of Medicine·Allen M Spiegel, Lee S Weinstein
Nov 26, 1998·Biosensors & Bioelectronics·I Lundström, S Svensson
Apr 1, 1999·Annual Review of Physiology·J AveryJ M Edwardson
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M BaradE Kandel
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I H McKillopJ V Sitzmann
Oct 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·John P CullenEileen M Redmond
Jun 23, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Alexey E LyashkovEdward G Lakatta
Jan 21, 2001·The Journal of Biological Chemistry·J H ZhangW F Simonds
Jun 10, 2020·ELife·André M LazarMark Von Zastrow
Jan 22, 2013·American Journal of Physiology. Heart and Circulatory Physiology·K M ClappA H Stephenson
Dec 15, 2010·The Journal of Biological Chemistry·Nadia DaniMaria Di Girolamo
Sep 25, 1998·The Journal of Biological Chemistry·C W DessauerA G Gilman
Feb 19, 2002·Brain Research. Developmental Brain Research·Ivanna IhnatovychPetr Svoboda

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