Visualizing the hydrodynamics in sieve-based lateral displacement systems

Scientific Reports
J P DijkshoornM A I Schutyser

Abstract

Deterministic lateral displacement (DLD) systems structure suspension flow in so called flow lanes. The width of these flow lanes is crucial for separation of particles and determines whether particles with certain size are displaced or not. In previous research, separation was observed in simplified DLD systems that did not meet the established DLD geometric design criteria, by adjusting the outflow conditions. We here investigated why these simplified DLD systems are able to displace particles, by experimentally investigating the hydrodynamics in the device. Flow lanes were visualized and the local flow velocities were measured using µPIV and compared with 2D fluid dynamics simulations. The size of the flow lanes strongly correlates with the local flow velocity (Vy and Vx), which depends on the hydrodynamics. Therefore, the geometric design criteria of DLD devices is in fact just one method to control the local hydrodynamics, which may also be influenced by other means. These findings give a new perspective on the separation principle, which makes the technique more flexible and easier to translate to industrial scale.

References

May 15, 2004·Science·Lotien Richard HuangJames C Sturm
May 3, 2006·Lab on a Chip·David W InglisJames C Sturm
Aug 25, 2006·Lab on a Chip·J de JongM Wessling
Jun 24, 2008·Advances in Colloid and Interface Science·T KulrattanarakR M Boom
Dec 7, 2010·Journal of Colloid and Interface Science·T KulrattanarakR M Boom
Jun 14, 2017·Proceedings of the National Academy of Sciences of the United States of America·Sung-Cheol KimGustavo Stolovitzky
Sep 2, 2017·Lab on a Chip·Rohan VernekarDavid W Inglis

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Citations

Jul 20, 2019·The Analyst·Byeong Seon ParkBong Geun Chung
Sep 17, 2019·Nano-micro Letters·Thoriq SalafiYong Zhang

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Software Mentioned

COMSOL
PIV
COMSOL Multiphysics
IMAGEJ
NIH
DaVis

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