Visualizing the vitreous body in the anterior chamber using 11-deoxycortisol after posterior capsule rupture in an animal model

Ophthalmology
Yuichi KajiTetsuro Oshika

Abstract

To develop a new technique to visualize vitreous body prolapsed in the anterior chamber using 11-deoxycortisol. Experimental study. An animal model of posterior capsule rupture was developed to investigate the usefulness of 11-deoxycortisol, a precursor of cortisol without steroid activity. After the intentional creation of posterior capsule rupture, the suspension of 11-deoxycortisol was injected into the anterior chamber of rabbit eyes. After gentle irrigation and aspiration, the vitreous body that had prolapsed into the anterior chamber was removed using an anterior vitrectomy cutter. To investigate the safety of 11-deoxycortisol, the biomicroscopic appearance, intraocular pressure (IOP), corneal endothelial count, and microstructure of the corneal endothelium were examined in the rabbits that received injections of 11-deoxycortisol in the anterior chamber. In our posterior capsule rupture model, the vitreous in the anterior chamber became clearly visible, with 11-deoxycortisol showing white particles entrapped on its surface. The injection of 11-deoxycortisol facilitated the complete removal of the vitreous body from the anterior chamber. In intact rabbit eyes, most of the injected 11-deoxycortisol had disappeared from the ...Continue Reading

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Citations

Jun 23, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Taiji Sakamoto, Tatsuro Ishibashi
May 10, 2005·Ophthalmology·Ravi Thomas
Apr 29, 2014·Journal of Cataract and Refractive Surgery·Shai M Bar-SelaMichaella Goldstein
Dec 13, 2005·Journal of Cataract and Refractive Surgery·Alex H FanDennis S C Lam
Mar 19, 2019·Journal of Cataract and Refractive Surgery·Takeshi SugiuraYoshikazu Tanaka

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