Visually-guided saccadic eye movements in adolescents at genetic risk for schizophrenia

Schizophrenia Research
H SchreiberH H Kornhuber

Abstract

Visually-guided saccades of 21 offspring of schizophrenic parents and 21 individually matched controls were compared with regard to the frequency of occurrence of saccadic hypometria and hypermetria, non-fixations, and omissions of target jumps. Target steps ranged from 10 to 60 degrees, and interstimulus intervals averaged 2.5 s; subjects were promised financial reward depending on performance. Recordings were carried out at the subjects' homes. To screen for cognitive abilities and psychopathological behavior, subjects were tested by means of an intelligence scale and a behavioral checklist. With large target steps (40-60 degrees), the high-risk group made significantly more grossly hypometric saccades (gain < or = 0.8) than the control group; responses to small target steps (10-30 degrees) exhibited a similar, albeit statistically not significant, trend. There were no significant differences with regard to the occurrence of hypermetria. Non-fixations scored marginally higher in the high-risks as compared to controls, but this was again not a significant difference. The incidence of omissions of saccades was very low in both groups. The results of the study suggest that subjects at genetic risk for schizophrenia may differ fr...Continue Reading

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Citations

Oct 7, 2008·Brain and Cognition·Nanda N J RommelseJoseph A Sergeant
Oct 26, 2005·Schizophrenia Research·Jason SchiffmanSarnoff A Mednick
Oct 31, 2017·Journal of Integrative Neuroscience·Elena L TeslenkoBoris K Baziyan

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