Visuo-spatial memory deficits following medial temporal lobe damage: A comparison of three patient groups

Neuropsychologia
Nazli Esfahani-BayerlChristoph J Ploner

Abstract

The contributions of the hippocampal formation and adjacent regions of the medial temporal lobe (MTL) to memory are still a matter of debate. It is currently unclear, to what extent discrepancies between previous human lesion studies may have been caused by the choice of distinct patient models of MTL dysfunction, as disorders affecting this region differ in selectivity, laterality and mechanisms of post-lesional compensation. Here, we investigated the performance of three distinct patient groups with lesions to the MTL with a battery of visuo-spatial short-term memory tasks. Thirty-one subjects with either unilateral damage to the MTL (postsurgical lesions following resection of a benign brain tumor, 6 right-sided lesions, 5 left) or bilateral damage (10 post-encephalitic lesions, 10 post-anoxic lesions) performed a series of tasks requiring short-term memory of colors, locations or color-location associations. We have shown previously that performance in the association task critically depends on hippocampal integrity. Patients with postsurgical damage of the MTL showed deficient performance in the association task, but performed normally in color and location tasks. Patients with left-sided lesions were almost as impaired as...Continue Reading

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Citations

Nov 5, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Owen Robert PhillipsCarsten Finke
Aug 3, 2017·Hippocampus·Anna PajkertChristoph J Ploner
Apr 29, 2018·Hippocampus·Sergej WuethrichKatharina Henke
Apr 23, 2019·The Journal of International Medical Research·Pei Wei ShanChuanjun Zhuo
Dec 21, 2017·Scientific Reports·Jens GemptFlorian Ringel
Mar 1, 2019·Frontiers in Psychology·Terry L DavidsonRichard J Stevenson

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