Vitamin A and fish oils for retinitis pigmentosa

The Cochrane Database of Systematic Reviews
Sobharani RayapudiPamela Chavis

Abstract

Retinitis pigmentosa (RP) comprises a group of hereditary eye diseases characterized by progressive degeneration of retinal photoreceptors. It results in severe visual loss that may lead to legal blindness. Symptoms may become manifest during childhood or adulthood, and include poor night vision (nyctalopia) and constriction of peripheral vision (visual field loss). This field loss is progressive and usually does not reduce central vision until late in the disease course.The worldwide prevalence of RP is one in 4000, with 100,000 patients affected in the USA. At this time, there is no proven therapy for RP. The objective of this review was to synthesize the best available evidence regarding the effectiveness and safety of vitamin A and fish oils (docosahexaenoic acid (DHA)) in preventing the progression of RP. We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (2013, Issue 7), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to August 2013), EMBASE (January 1980 to August 2013), Latin American and Caribbean Health Sciences Literature Database (LILACS) (January 1982 to August 2013), the metaRegister of Controlled Trials (...Continue Reading

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Citations

Jul 14, 2018·The Journal of Biological Chemistry·Andrew TsinJeffery Grigsby
Jan 9, 2019·Journal of Neural Engineering·Andrey M DemchinskyDmitry V Polikanov
Jun 24, 2020·The Cochrane Database of Systematic Reviews·Stephen G SchwartzSamuel A Abariga
Nov 16, 2016·Oman Journal of Ophthalmology·Rahul DeshpandeRajiv Khandekar
Jun 19, 2014·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·David M Cockburn
Mar 29, 2019·Journal of Ophthalmology·Ying ZhaoXuejing Lu
Jul 17, 2021·Biochimica Et Biophysica Acta. Molecular Cell Research·Yanel A VolontéOlga L German

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