Vitamin A and inflammatory bowel diseases: from cellular studies and animal models to human disease

Expert Review of Gastroenterology & Hepatology
Sandra Maria BarbalhoGabriela Lombardi Dos Santos Almeida Batista

Abstract

Vitamin A (VA) and metabolites such as Retinoic Acid (RA) and all-trans-RA (at-RA) are crucial in the modulation of the immune system and may be determinative in the balance of the immune responses. Inflammatory bowel diseases (IBD) consist of chronic relapsing and heterogeneous disorders with not well-known etiology. Due to its role in inflammatory processes, VA may be helpful in the treatment of IBD. Area covered: As VA plays a significant role in the inflammatory processes, this review aims to show the potential role of this vitamin in IBD, searching for cellular studies, animal models, and studies with humans. Expert commentary: Many studies have described the importance of alternative therapeutic approaches for IBD. Due to its role in the immune system, VA may also exert an indispensable role in the IBD. Nevertheless, some authors have shown that these compounds could stimulate the release of pro-inflammatory cytokines. For these reasons, more studies should be performed to establish the precise mechanisms of VA and its metabolites in systemic and intestinal inflammation.

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Citations

Aug 30, 2019·Journal of Clinical Medicine·Johannes HausmannIrina Blumenstein
Jun 3, 2020·Seminars in Cancer Biology·Carsten Carlberg, Alberto Muñoz
Feb 16, 2021·Journal of Lipid Research·Maryam HonarbakhshLoredana Quadro
Feb 18, 2021·Journal of Physiology and Biochemistry·Qinghui JiaMinshan Feng

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