PMID: 96868Jun 15, 1978Paper

Vitamin A and thyroxine carrier proteins in chicken plasma: steady-state control of the plasma level of free retinol-binding protein and free thyroxine

Biochimica Et Biophysica Acta
M K Bhat, H R Cama

Abstract

1. The binding parameters of prealbumin-2 with retinol-binding protein and thyroxine (T4) revealed the existence of distinct and multiple sites for both retinol-binding protein and T4. 2. From the analysis of binding parameters of retinol-binding protein with prealbumin-2 it is clear that under steady-state conditions about 99% of the holo-retinol-binding protein remains bound to prealbumin-2. 3. Equilibrium dialysis studies on binding properties of thyroid hormones with prealbumin-2 revealed that it has a single high affinity site and three low affinity sites. 4. The occurrence of three carrier proteins for thyroid hormones, thyroxine-binding globulin, prealbumin-2 and albumin has been demonstrated. However, the chicken thyroxine-binding globulin differs from human thyroxine-binding globulin by being relatively less acidic and occurring at a two-fold lower concentration. But the thyroid hormone binding parameters are comparable. 5. Highly sensitive methods were developed for determination of T4 binding capacities of the various proteins and plasma level of total T4 by fractionation of carrier proteins and further quantitatively employing in electrophoresis and equilibrium dialysis. 6. The thyroxine-binding proteins were found ...Continue Reading

References

Oct 9, 1973·Biochemistry·P L LuisiD Karlovic
Jan 1, 1974·Vitamins and Hormones·J GloverG H White
Sep 1, 1971·European Journal of Clinical Investigation·P A Peterson
Jul 21, 1972·Biochimica Et Biophysica Acta·A M GottoD S Goodman
Nov 1, 1971·The Journal of Clinical Investigation·F R Smith, D S Goodman
Dec 23, 1969·Journal of Chromatography·A D WilliamsW H Florsheim
Sep 1, 1968·The Journal of Clinical Investigation·M KanaiD S Goodman
May 1, 1962·Endocrinology·L S FARERJ E RALL
Feb 1, 1964·The Journal of Clinical Endocrinology and Metabolism·B E MURPHY, C J PATTEE
Dec 28, 1964·Annals of the New York Academy of Sciences·B J DAVIS

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Citations

Jan 1, 1985·Neurochemistry International·J Nunez
Feb 1, 1980·The American Journal of Physiology·J E MorleyJ M Hershman
Dec 1, 1993·Molecular and Cellular Endocrinology·A Tsykin, G Schreiber

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