Vitamin A and urolithiasis

Clinica Chimica Acta; International Journal of Clinical Chemistry
F GrasesJ G March

Abstract

The effects of vitamin A deficiency on urolithiasis were investigated in male rats. A vitamin A-deficient diet caused important changes in the composition of the urine of the treated rats when compared with controls. One of the main effects was a decrease in the concentration of urinary glycosaminoglycans and zinc in the rats receiving the vitamin A-deficient diet. Significant differences were also found in plasma vitamin E and in the relation of vit E/vit A between treated and control groups but, in general, with no important differences in vitamin A. Nevertheless, significant differences in kidney content of vitamin A were observed between both groups. On the other hand, lesions of the cuboidal epithelium that covers the papillae in rats treated with the vitamin A-deficient diet were severe when compared with controls. The vitamin A and E plasma levels in urolithiasic humans were also investigated and compared with those found in a control group. No significant differences were observed in plasma vitamin A levels; nevertheless a significant increase in vitamin E and in the vit E/vit A ratio was clearly observed. These results could be related to a possible deficit of vitamin A in kidneys of stone formers, this being one of th...Continue Reading

References

Apr 1, 1981·The American Journal of Clinical Nutrition·S N Gershoff, R B McGandy
Jul 1, 1995·Biological Trace Element Research·A S RahmanY Itokawa
Jan 1, 1994·Nephron·F GrasesJ G March
Sep 1, 1994·British Journal of Urology·F GrasesJ G March
Jan 1, 1993·Urologia Internationalis·F GrasesA Conte
Jan 1, 1995·International Urology and Nephrology·F GrasesA Costa-Bauzá

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Citations

Sep 22, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Mourad BardaouiAbdelhamid El Hani
Nov 25, 2003·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·J RailaF J Schweigert
Sep 22, 2017·Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·Julia K Mack, Ellen Kienzle

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