PMID: 9165000May 1, 1997Paper

Vitamin A deficiency exacerbates methotrexate-induced jejunal injury in rats

The Journal of Nutrition
R A WardenE V O'Loughlin

Abstract

Two studies were conducted to investigate whether vitamin A-deficient rats were more susceptible to intestinal injury caused by methotrexate (MTX), since vitamin A deficiency alone causes only mild changes to jejunal structure and function. Weanling male rats were fed a vitamin A-deficient diet (-VA) for 40-42 d and compared to rats either pair-fed (PF) or with free access (+VA) to the same diet. Drinking water of PF and +VA rats was supplemented with 37.5 microg (Study 1) or 75 microg (Study 2) vitamin A (Rovimix A 500W)/d. Rats in each group received MTX (-VAMTX, PFMTX, +VAMTX) or vehicle. MTX administration reduced intestinal mucosal wet weight, protein and DNA concentrations, and sucrase and maltase activities in -VA and PF rats (P < 0.02). In Study 1, -VAMTX rats developed a severe jejunal enteropathy and had a higher incidence of diarrhea (P < 0.005), greater weight loss (P < 0.005), more disruption of villus architecture (P < 0.0001) and lower disaccharidase activity (P < 0.007) than PFMTX rats. Similar results were observed in Study 2. Liver retinol concentration (but no other variable) was greater in rats receiving 75 microg vitamin A/d (P < 0.001) than in those receiving 37.5 microg/d. The interaction of vitamin A def...Continue Reading

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Citations

Feb 7, 2008·Archives of Toxicology·Viswa Kalyan KolliSuganthy Rabi
Mar 11, 2003·Annual Review of Nutrition·Thomas R ZieglerDean P Jones
Apr 27, 2002·The American Journal of Clinical Nutrition·Christopher DugganW Allan Walker
Jul 2, 2002·International Journal of Food Sciences and Nutrition·D O EdemI B Umoh
Nov 20, 2014·BMC Gastroenterology·Stephan C BischoffJerry M Wells
Dec 27, 2019·Human & Experimental Toxicology·T HiguchiH Furukawa
Apr 20, 2000·JPEN. Journal of Parenteral and Enteral Nutrition·D A Swartz-BasileM S Levin
Jan 11, 2000·The Proceedings of the Nutrition Society·S M Filteau
Oct 20, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M L McWilliamsM Friedman

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