Vitamin A deficiency impairs postnatal cognitive function via inhibition of neuronal calcium excitability in hippocampus

Journal of Neurochemistry
Wei JiangTingyu Li

Abstract

Vitamin A (VA) is important for postnatal brain development, and VA deficiency (VAD) can cause learning and spatial memory deficits in rats. Most of the biological functions of VA are mediated by retinoic acid (RA). To investigate the mechanisms underlying VA deficits, mother rats were fed elemental diets to achieve blood VA levels classified as normal, deficient or severely deficient. Shuttle box and Morris water maze tests revealed impairments in learning ability and spatial memory, respectively, in adolescent VAD rats (p 30-35). Electrophysiology showed weaker long-term potentiation in VAD rats compared to VA normal rats. Examination of NMDA-induced calcium (Ca(2+) ) excitability revealed decreased excitability in hippocampal slices from VAD rats during postnatal development. Relative to VA normal rats, VAD rats also had decreased NMDA receptor NR1 mRNA and protein expression in later stages of postnatal development (p 10-30), as well as differences in retinoic acid receptor (RARα) mRNA and protein expression. Furthermore, primary hippocampal neurons in culture showed increased neuronal Ca(2+) excitability in response to all-trans-RA or 9-cis-RA, coupled with increases in RARα and NR1 expression similar to those observed in ...Continue Reading

References

Feb 1, 1995·Trends in Neurosciences·G L Collingridge, T V Bliss
Jul 28, 1995·The Journal of Biological Chemistry·S B KurlandskyW S Blaner
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D P YounkinD Pleasure
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Mar 29, 1996·Brain Research. Developmental Brain Research·J LuoB B Wolfe
Feb 1, 1997·The International Journal of Biochemistry & Cell Biology·A Rowe
Mar 21, 1998·The Journal of Nutrition·A Lucas
Jun 5, 1999·Cellular and Molecular Life Sciences : CMLS·J Micheau, G Riedel
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·D L MisnerR M Evans
Feb 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Elizabeth A Werner, Hector F Deluca
May 10, 2002·Annals of the New York Academy of Sciences·B S McEwen
Nov 5, 2002·Nature Reviews. Neuroscience·Malcolm Maden
Jul 2, 2003·Experimental and Molecular Pathology·Hirotake TakaiKunio Doi
Aug 13, 2003·The European Journal of Neuroscience·P J McCafferyE Rosa-Molinar
Sep 6, 2003·The European Journal of Neuroscience·Amanda J LawPaul J Harrison
Jan 13, 2004·Physiological Reviews·M A Lynch
Apr 30, 2004·Biology of Reproduction·Dawn OwenStephen G Matthews
May 11, 2005·Progress in Neurobiology·Michelle A Lane, Sarah J Bailey
Feb 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shaomin LiLarry A Feig
Mar 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Sharoni JacobsRonald M Evans
May 12, 2006·Journal of Neurobiology·Peter McCafferyJames E Crandall
Jun 8, 2006·Neuroscience·A M Hernández-PintoE Arilla-Ferreiro
Aug 26, 2006·Science·Tim V P BlissSerge Laroche
Feb 23, 2007·Neuroreport·Roberto StancampianoFabio Fadda
May 22, 2007·Nature Reviews. Neuroscience·C Geoffrey Lau, R Suzanne Zukin
Aug 23, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Na Chen, Joseph L Napoli
Aug 30, 2007·Critical Reviews in Neurobiology·John F MacDonaldMichael A Beazely
Jan 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Frédérique MingaudAline Marighetto
Jul 12, 2008·Annual Review of Cell and Developmental Biology·Sonia Cohen, Michael E Greenberg
Sep 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Maximilian H Ulbrich, Ehud Y Isacoff
Sep 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Elodie FourcaudotAndreas Lüthi
Oct 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bita MaghsoodiLu Chen
Dec 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Michael M Poon, Lu Chen

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Citations

Jun 18, 2014·International Journal of Medical Sciences·Nali HouTingyu Li
Sep 11, 2012·Trends in Neurosciences·Kirsty D ShearerPeter J McCaffery
Jan 16, 2013·The International Journal of Biochemistry & Cell Biology·Min GongTingyu Li
Nov 29, 2014·Frontiers in Cellular Neuroscience·Antonio Benítez-Burraco, Cedric Boeckx
Sep 14, 2016·Frontiers in Neuroscience·Antonio Benítez-BurracoElliot Murphy
Aug 8, 2015·Anais Da Academia Brasileira De Ciências·Marcos Roberto de Oliveira
Oct 16, 2019·Journal of Neuroendocrinology·Damien BonhommeKatia Touyarot
Sep 24, 2020·Annual Review of Nutrition·Marta U Wołoszynowska-FraserPeter McCaffery
Oct 1, 2012·Dementia & Neuropsychologia·Yara Dadalti FragosoFernanda Jussio Guillen
Jan 5, 2019·Journal of Molecular Neuroscience : MN·Geir BjørklundJoanna Kałużna-Czaplińska
Jan 29, 2017·Acta Neuropathologica·Jiaying ZengWeihong Song
Aug 10, 2019·Frontiers in Aging Neuroscience·Malena Dos Santos GuilhermeKristina Endres
Nov 24, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Essi F BiyongGuillaume Ferreira

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