Vitamin A does not influence mRNA expression of hormone hepcidin but other biomarkers of iron homeostasis in young male Wistar rats

International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition
Mauricio Restrepo-Gallego, Luis E Díaz

Abstract

The effects of an adequate supply of vitamin A and iron, in comparison with diets low or absent in vitamin A and low in iron, on the mRNA expression of some biomarkers of iron homeostasis as hepcidin (Hamp), transferrin receptor-1 (Tfrc), iron regulatory protein-2 (Ireb2) and ferritin (Fth1) in rats were investigated. 35 male Wistar rats were randomly divided into 5 dietary groups: control, sufficient in iron and insufficient in vitamin A (FesvAi), sufficient in iron and depleted in vitamin A (FesvAd), insufficient in iron and sufficient in vitamin A (FeivAs) and insufficient in both iron and vitamin A (FeivAi). After 6 weeks rats showed no significant effects of variations in vitamin A on the expression of Hamp relative to the control group (FesvAi: 1.37-fold; FesvAd: 1.22-fold); however, iron deficiency showed significant reduction on it relative to the control group (FeivAs: 71.4-fold, P = 0.0004; FeivAi: 16.1-fold, P = 0.0008). Vitamin A deficiency (FesvAd) affects expression of Fth1 independent of low dietary iron in spleen (0.29-fold, P = 0.002) and duodenum (5.15-fold, P = 0.02). Variations of dietary iron and vitamin A showed significant effects relative to the control group for expression of Tfrc in spleen (FesvAd: 0.1...Continue Reading

References

May 1, 1997·The Journal of Nutrition·P G Reeves
Feb 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Pauline LeeErnest Beutler
Apr 1, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nadeem SheikhGiuliano Ramadori
May 23, 2006·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Janet R Hunt
Oct 5, 2006·Food and Nutrition Bulletin·Keith P West
Jun 5, 2007·Cadernos de saúde pública·Rute Cândida PereiraJosé Natal Figueirôa
Feb 22, 2008·Nutrition Reviews·Julicristie M OliveiraPatrícia H C Rondó
Apr 9, 2008·Cell Metabolism·Tomas Ganz
Feb 17, 2009·Nutrition·Sandra Fernandes ArrudaFernando Fortes de Valência
Mar 2, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jodie L Babitt, Herbert Y Lin
Feb 22, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Bhawna SinghS K Gupta
Apr 25, 2012·Biological Trace Element Research·Marta CitelliCristiana Pedrosa
May 12, 2012·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Brie K FuquaGregory J Anderson
Jun 19, 2013·PloS One·Sumithra MuthayyaRobert E Black
Nov 20, 2013·Journal of Pharmacology & Pharmacotherapeutics·Jaykaran Charan, N D Kantharia
Mar 5, 2014·Hematology/oncology Clinics of North America·Paul J Schmidt, Mark D Fleming
Jun 24, 2014·Jornal de pediatria·Bárbara C A SaraivaPaula M Horta
Jun 26, 2014·Biological Trace Element Research·Wei-Na KongShu-E Zhao
Jul 8, 2014·The Journal of Nutritional Biochemistry·Marcela S B da CunhaSandra F Arruda
Aug 15, 2014·Frontiers in Pharmacology·Nicole Wilkinson, Kostas Pantopoulos
May 18, 2016·Nucleic Acids Research·Sasha BabickiDavid S Wishart
Feb 13, 2017·The Medical Clinics of North America·Michael J Cascio, Thomas G DeLoughery
Jun 29, 2017·Nutrients·Mustapha Umar ImamFudi Wang
Oct 29, 2017·Hematology/oncology Clinics of North America·Julie T Vieth, David R Lane
Nov 21, 2017·World Journal of Gastroenterology : WJG·Ihtzaz Ahmed MalikNaila Naz
Jan 18, 2018·Critical Reviews in Food Science and Nutrition·Marcela de Sá Barreto da CunhaSandra Fernandes Arruda

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Methods Mentioned

BETA
atomic absorption spectrometry
PCR
ELISA

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