Vitamin A inhibits cytokines produced by type 1 lymphocytes in vitro

Cellular Immunology
S FrankenburgY Milner

Abstract

The effect of vitamin A (retinol) on cell-mediated immune responses was studied. As an experimental model, Leishmania major infection in mice was used. In this model, resistant mouse strains develop a type 1 response, while susceptible strains develop a type 2 response. Using lymph node cells and T-cell lines developed from infected susceptible and resistant mice, it was found that vitamin A inhibited lymphocyte proliferation in a dose-dependent manner. By separately incubating antigen-presenting cells and T cells with vitamin A, it was shown that the inhibitory effect was on the T cells. Type 1 cytokine (IFN-gamma, GM-CSF, IL-2) secretion in vitro in response to stimulation with specific antigen was also inhibited in a dose-dependent manner, whereas secretion of type 2 cytokines (IL-4 and IL-10) was not affected by vitamin A. The inhibitory effect was also observed in PMA-stimulated (but not Con A-stimulated) lymphocytes and was noticeable even if the vitamin was added as late as 24 h after initiation of the incubation period. Since PMA does not operate via a receptor-coupled signaling pathway but rather directly affects the protein kinase C (PKC) pathway, we have measured the effect of vitamin A on PKC in situ activation. Inc...Continue Reading

Citations

Aug 7, 2008·International Urology and Nephrology·Reginald M Gorczynski, Ender Terzioglu
May 26, 2001·Annual Review of Nutrition·C B Stephensen
Feb 24, 2006·The Veterinary Journal·S MilletG P J Janssens
Jun 14, 2003·Annals of Tropical Medicine and Parasitology·Y MizunoH Ohtomo
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Charles B StephensenR Patterson Bucy
Mar 27, 2007·The Veterinary Clinics of North America. Food Animal Practice·Jeffery A Carroll, Neil E Forsberg

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