PMID: 6974252Jul 1, 1981Paper

Vitamin A inhibits some aspects of systemic disease due to local x-radiation

JPEN. Journal of Parenteral and Enteral Nutrition
E SeifterS M Levenson

Abstract

We have previously reported that supplemental vitamin A ameliorates the stress response to a wide variety of noxious agents. The present study was carried out to determine how supplemental vitamin A influences the course of radiation sickness in C3H female mice subjected to 3000 R irradiation of one lower hind limb. All mice ingested a chow diet containing about 13,000 units of vitamin A/kg diet (about half as preformed vitamin A and half as beta-carotene) which supports normal growth, development, and reproduction of normal mice. One hundred fifty thousand units of vitamin A/kg chow was added for the vitamin A supplemented mice. All mice ate and drank ad libitum. The supplemental vitamin A feeding was begun either 3 days before radiation or immediately after radiation. There were no significant differences in the effects of these two regimens. The supplemental vitamin A prevented the weight loss, moderated the adrenal hypertrophy, prevented the thymic involution, and lessened the lymphopenia due to radiation. We conclude that supplemental vitamin A has both prophylactic and therapeutic benefits in radiation-induced disease.

References

May 1, 1978·JPEN. Journal of Parenteral and Enteral Nutrition·A BarbulE Seifter
Jun 1, 1975·Journal of the National Cancer Institute·G RetturaE Seifter
Mar 1, 1974·Journal of the National Cancer Institute·D BrandesH Ueda
May 28, 1970·The New England Journal of Medicine·M M Mathews-RothE H Kass
Feb 5, 1949·Journal of the American Medical Association·G J DAMMIN, S C BUKANTZ
Jul 1, 1949·The Journal of Allergy·C FORMANW E EHRICH

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