PMID: 6539664Jun 1, 1984Paper

Vitamin A is present as retinol in the tears of humans and rabbits

Current Eye Research
J L Ubels, S M MacRae

Abstract

Vitamin A is required for the normal growth maintenance and maturation of the corneal epithelium and is effective in the treatment of xerophthalmia and experimental corneal epithelial wounds when applied topically as retinoic acid. The normal route of delivery of vitamin A to the cornea has remained undefined. We collected tears from normal and vitamin A deficient rabbits and from humans and analyzed them by high pressure liquid chromatography. A peak corresponding to a retinol standard was eluted from normal rabbit and human tears but was absent from the vitamin A deficient rabbit tears. The retinol concentration in rabbit tears was 69 ng/ml (0.2 X 10(-6)M) and in human tears was 16 ng/ml (0.5 X 10(-7)M). This demonstration that vitamin A is present in the tears as retinol establishes the rationale for treatment of corneal disease with topical vitamin A.

References

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Citations

Jan 1, 1995·The British Journal of Ophthalmology·F W FraunfelderD R Illingworth
Oct 12, 2012·Clinical Ophthalmology·Akito OdakaAkira Murakami
Nov 1, 1993·Current Eye Research·B J GlasgowJ B Bateman
May 1, 1995·Current Eye Research·B J GlasgowW L Hubbell
Oct 14, 2008·American Journal of Ophthalmology·Eun Chul KimChoun-Ki Joo
Jul 1, 1988·Journal of the American Academy of Dermatology·M A Lebowitz, D S Berson
Aug 1, 1988·Journal of the American Academy of Dermatology·V RismondoT B Osgood
Jul 1, 1992·Experimental Eye Research·S Y LeeD R Soprano
Oct 1, 1992·Experimental Eye Research·A DelaireA M Gachon
Dec 24, 2016·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Nobuhito TabuchiAkira Murakami
Mar 26, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Prativa B S Dawadi, Johan Lugtenburg
Jun 12, 2019·Advanced Healthcare Materials·Rosalia MoredduAli K Yetisen
Nov 1, 1995·Current Eye Research·J L UbelsP R Kinchington
Nov 26, 2008·Alternatives to Laboratory Animals : ATLA·Judith W SeeberMaria Engelke
Apr 16, 1998·Progress in Retinal and Eye Research·A Sommer
Aug 31, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·F Meijer, N J van Haeringen

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