Vitamin A Palmitate and Carbomer Gel Protects the Conjunctiva of Patients With Long-term Prostaglandin Analogs Application

Journal of Glaucoma
Xinhan CuiXiaodong Zhou

Abstract

To investigate the protective effects of vitamin A palmitate and carbomer gel on the morphology of conjunctival epithelium and density of goblet cells (GCs) in patients on long-term prostaglandin analogs (PGAs) application. In this prospective cohort study, 23 primary open-angle glaucoma patients and 7 normal-tension glaucoma patients prescribed PGAs for >1 year were enrolled into 3 identical clinical trials and randomized into 3 groups (10 per group). Patients were treated twice daily with vitamin A palmitate eye gel 0.1%, or carbomer eye gel 0.2%, or no additional application of these 2 drugs. Ocular surface disease index questionnaires, Schirmer 1 test without anesthesia, tear break-up time test, and GCs density assessment by in vivo confocal microscopy and conjunctival impression cytology analysis were performed at baseline and at months 1, 3, and 6 of the study. Both vitamin A palmitate and carbomer gel led to a significant improvement in ocular surface disease index questionnaires score and prevented the gradual decline in tear break-up time. Vitamin A palmitate significantly increased the GC density after treatment. The GC density assessed by in vivo confocal microscopy positively correlated with that measured by conjunc...Continue Reading

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Citations

Mar 17, 2018·Nutrients·Wishal D RamdasCarroll A B Webers
Aug 24, 2017·Acta Ophthalmologica·Sophia Seen, Louis Tong
Sep 11, 2018·Eye & Contact Lens·Xuemin ZhangOsamah Saeedi

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Methods Mentioned

BETA
confocal microscopy

Software Mentioned

SPSS
Polyquad
IVCM

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