Vitamin A status affects the development of diabetes and insulitis in BB rats

Metabolism: Clinical and Experimental
H K DriscollA B Pofahl

Abstract

BB/Wor rats develop autoimmune diabetes mellitus with many features in common with human insulin-dependent diabetes mellitus. Since retinoids are known to have effects on insulin secretion and immune function, these studies were designed to investigate the effects of retinoid deficiency on diabetes in BB/Wor rats and to identify a role for retinoid status in the pathogenesis of autoimmune diabetes mellitus. Litters of diabetes-prone (DP) and diabetes-resistant (DR) BB/Wor rats were divided at weaning and fed a diet either (1) devoid of retinoids and leading to clinical deficiency at approximately 60 days of age (A-def diet)-following 10 days of clinical deficiency, rats on the A-def diet were changed to a diet containing 2 microg/g retinoic (A-def/RA diet); (2) containing 2 microg/g retinoic acid but deficient in retinol (RA diet); or (3) replete in retinol with 4 microg/g retinyl palmitate (RP diet). Rats receiving RP or RA diets were pair-fed to rats on the A-def/RA diet. Diabetes by 120 days of age was greatly reduced (P < .01) in DP rats that received the A-def/RA diet (four of 27) or RA diet (four of 29) versus the RP diet (13 of 31). Insulitis progressed with age in nondiabetic DP rats receiving the RP diet (P < .02) or R...Continue Reading

References

Nov 1, 1992·Diabetes·C MathieuR Bouillon
Jul 1, 1992·The Journal of Experimental Medicine·A GarbeU Hämmerling
Apr 1, 1992·Diabetes/metabolism Reviews·L CrisáA A Rossini
Mar 1, 1991·Canadian Journal of Physiology and Pharmacology·F W Scott, E B Marliss
Dec 13, 1991·Science·J BuckU Hämmerling
May 1, 1990·The Journal of Experimental Medicine·J BuckU Hämmerling
Feb 1, 1990·Endocrinology·H K DriscollA A Rossini
Aug 1, 1987·The Journal of Experimental Medicine·D L GreinerA A Rossini
Feb 1, 1987·Biulleten' eksperimental'noĭ biologii i meditsiny·I V GmoshinskiĭI Ia Kon'
Dec 1, 1974·The Journal of Clinical Investigation·G C WeirD B Martin
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher
Apr 1, 1984·Diabetologia·R B Elliott, J M Martin
Sep 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R D Semba
Jul 1, 1993·Diabetes Research and Clinical Practice·H MarkholstA Lernmark

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Citations

Sep 18, 1997·Nutrition·T K Basu, C Basualdo
Dec 20, 2000·The Journal of Nutritional Biochemistry·J LuT K Basu
Dec 8, 2004·Nature Medicine·Bengt Johansson-Lindbom, William W Agace
Dec 1, 2010·Proceedings of the National Academy of Sciences of the United States of America·Maureen A KaneJoseph L Napoli
Jun 15, 2011·Molecular and Cellular Biology·Maureen A KaneJoseph L Napoli
Feb 2, 2012·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Shi ZhaoGuoxun Chen
Nov 5, 2015·Diabetes Management·Steven E Trasino, Lorraine J Gudas
Oct 16, 2004·Immunity·Makoto IwataSi-Young Song
Oct 11, 2011·Biochimica Et Biophysica Acta·Maureen A Kane
Jun 28, 2012·Diabetes & Metabolism Journal·Eun-Jung Rhee, Jorge Plutzky
Sep 16, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D J FigueroaC P Austin
Aug 6, 2014·Nutrition and Metabolic Insights·Yoon Sin Oh, Hee-Sook Jun
Aug 12, 2008·The American Journal of Clinical Nutrition·Liisa UusitaloMikael Knip
Mar 27, 2019·Proceedings of the National Academy of Sciences of the United States of America·Peng GaoKai Tan
Nov 25, 2020·Journal of Medicinal Food·Yan ZhangGuoxun Chen
Mar 9, 2021·Frontiers in Endocrinology·Yunting ZhouJianhua Ma

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