Vitamin A status affects weight gain and hepatic glucose metabolism in rats fed a high-fat diet

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
Heqian KuangGuoxun Chen

Abstract

Whether vitamin A (VA) has a role in the development of metabolic abnormalities associated with intake of a high-fat diet (HFD) is unclear. Sprague-Dawley rats after weaning were fed an isocaloric VA sufficient HFD (VAS-HFD) or a VA deficient HFD (VAD-HFD) for 8 weeks. Body mass, food intake, liver and adipose tissue mass, and the hepatic expression levels of key proteins for metabolism were determined. VAD-HFD rats had lower body, liver, and epididymal fat mass than VAS-HFD rats. VAD-HFD rats had lower hepatic protein expression levels of cytochrome P450 26A1, glucokinase, and phosphoenolpyruvate carboxykinase than VAS-HFD rats. VAD-HFD rats had higher protein levels of glycogen synthase kinase (GSK)-3α and lower levels of GSK-3β, but not glycogen synthase, than VAS-HFD rats. VAD-HFD rats had higher hepatic levels of insulin receptor substrate-1 (IRS-1), insulin receptor β-subunit, mitogen-activated protein kinase proteins, and peroxisome proliferator-activated receptor-gamma coactivator 1α mRNA, and lower level of IRS-2 protein than VAS-HFD rats. These results indicate that in a HFD setting, VA deficiency attenuated HFD-induced obesity, and VA status altered the expression levels of proteins required for glucose metabolism an...Continue Reading

References

Oct 1, 1972·The American Journal of Clinical Nutrition·R W Hanson, A J Garber
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·H Eldar-Finkelman, E G Krebs
Jun 11, 2002·Archives of Biochemistry and Biophysics·Yuanping WangA Catharine Ross
Jan 14, 2003·Nature Medicine·Sean B JosephPeter Tontonoz
Aug 18, 2004·Genes & Development·Nissim Hay, Nahum Sonenberg
Mar 12, 2005·Annual Review of Public Health·Matthias B Schulze, Frank B Hu
May 12, 2006·Journal of Neurobiology·Rune Blomhoff, Heidi Kiil Blomhoff
Aug 17, 2006·The Journal of Biological Chemistry·Min-Huei Liang, De-Maw Chuang
Aug 30, 2008·Cellular and Molecular Life Sciences : CMLS·P B Iynedjian
Jan 29, 2009·The Biochemical Journal·Guoxun ChenA Catharine Ross
Jul 8, 2010·Molecular and Cellular Biochemistry·C L GentileMichael J Pagliassotti
Dec 24, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Donald B Jump
Mar 18, 2011·The New England Journal of Medicine·Susan Z Yanovski, Jack A Yanovski
May 5, 2012·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yan ZhangGuoxun Chen
May 1, 2015·Endocrine Journal·Mototsugu NagaoShinichi Oikawa
Jun 26, 2015·International Journal of Molecular Sciences·Rui ZhangGuoxun Chen
Jan 1, 2014·Journal of Clinical Medicine·Wei Chen, Guoxun Chen

❮ Previous
Next ❯

Citations

Jan 25, 2021·The Journal of Biological Chemistry·Alla V KlyuyevaNatalia Y Kedishvili
Mar 3, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·M Luisa BonetAndreu Palou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asprosin

Asprosin is a fasting-induced hormone produced in the white adipose tissue to stimulate the hepatic release of glucose into the bloodstream. Discover the latest research on this protein hormone here.

Artificial Heart & Ventricular Assist Devices

Total artificial hearts (TAH) and ventricular assist devices (VADs) provide cardiac support for patients with end-stage heart disease and have significantly improved the survival of these patients. Discover the latest research on Artificial Heart and Ventricular Assist Devices here.

Related Papers

Biochemical and Biophysical Research Communications
Brice EmanuelliC Ronald Kahn
Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Jiacheng ZuoSihua Gao
© 2022 Meta ULC. All rights reserved