Vitamin A status, hospitalizations, and other outcomes in young children with sickle cell disease

The Journal of Pediatrics
Joan I SchallVirginia A Stallings

Abstract

To determine the relation of serum vitamin A status to growth, nutritional and hematologic status, and to the number of hospitalizations in children with sickle cell disease-SS (homozygous for the S allele, SCD-SS). Children (2-9.9 years of age) with SCD-SS were assessed for serum retinol, hemoglobin, hematocrit, reticulocyte count, height, weight, body mass index, and recalled dietary intake. Vitamin A status was defined on the basis of serum retinol concentration as suboptimal (<30 microg/dL) and normal (> or =30 microg/dL). Hospitalizations were determined for 1 year after vitamin A assessment. Mean serum retinol was 26.7 +/- 6.8 microg/dL in 66 subjects (39 girls) and was suboptimal in 66% of children. Compared with those with normal status, children with suboptimal vitamin A had significantly lower body mass index z score (-0.7 +/- 1.0 vs -0.1 +/- 0.6) and hemoglobin (7.9 +/- 1.1 vs 8.5 +/- 1.1), and hematocrit (23.3 +/- 3.0 vs 25.1 +/- 3.8) and significantly more hospitalizations (2.8 +/- 2.0 vs 0.7 +/- 0.8). After adjusting for age and sex, suboptimal vitamin A status was associated with a 10-fold increased risk for hospitalization (OR, 10.5; 95% CI, 2.3, 48.6) and with increased pain (OR,5.3; 95% CI, 1.3, 21.6) and feve...Continue Reading

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Citations

Jan 14, 2011·Journal of Pediatric Hematology/oncology·Kelly A DoughertyBabette S Zemel
Aug 30, 2008·Annals of Tropical Paediatrics·A-W M Al-SaqladiB J Brabin
May 10, 2005·British Journal of Haematology·Antonio Almeida, Irene Roberts
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Jul 14, 2009·Annals of Human Biology·Babette Zemel
Nov 26, 2019·Journal of Pediatric Hematology/oncology·Jefferson N BrownellVirginia A Stallings
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Aug 6, 2019·Frontiers in Immunology·Rhiannon R PenkertJulia L Hurwitz
Mar 11, 2020·Frontiers in Pediatrics·Dominik OchocinskiNiranjan Kissoon
May 14, 2009·Pediatric Hematology and Oncology·Monica J MitchellJennie Noll

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