PMID: 9665113Jul 17, 1998Paper

Vitamin A supplementation and severity of pneumonia in children admitted to the hospital in Dar es Salaam, Tanzania

The American Journal of Clinical Nutrition
W W FawziG Ndossi

Abstract

Vitamin A deficiency and acute lower respiratory tract infections coexist as important public health problems in many developing countries. We carried out a randomized, double-blind, placebo-controlled trial to examine whether large doses of vitamin A given to Tanzanian children who are admitted to the hospital with nonmeasles pneumonia would reduce the severity of respiratory disease. Six hundred eighty-seven children were randomly assigned to receive either placebo or vitamin A [200 000 IU (60 mg retinol equivalents) for children > 1 y of age and 100000 IU (30 mg retinol equivalents) for infants] on the day of admission and another dose on the following day. Of the 346 children in the vitamin A group, 13 died in the hospital, compared with 8 of 341 children in the placebo group; the relative mortality was 1.63 (95% CI: 0.67, 3.97; P = 0.28). The mean number of days of hospitalization was the same in both groups (4.2 d). There were no differences between the vitamin A and placebo groups in the duration of hospital stay when examined within categories of children stratified by age, sex, breast-feeding status, nutritional status at baseline, or quartile of dietary vitamin A intake in the 4 mo before admission to the hospital. Th...Continue Reading

Citations

Apr 2, 2010·International Journal of Epidemiology·Evropi TheodoratouHarry Campbell
May 29, 2007·Indian Journal of Pediatrics·H M SwamiS P S Bhatia
Jul 22, 2005·The Cochrane Database of Systematic Reviews·J NiT Wu
Dec 21, 2006·Tropical Medicine & International Health : TM & IH·Henrik Friis
Oct 30, 2016·International Journal of Epidemiology·Emily R SmithWafaie Fawzi
Aug 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·Carole Seguin-DevauxDan Longrois
Dec 3, 2003·Tropical Medicine & International Health : TM & IH·Eduardo VillamorWafaie W Fawzi
Oct 7, 2005·American Journal of Epidemiology·Christian L ColesRon Dagan
Feb 7, 2008·The Cochrane Database of Systematic Reviews·H ChenT Wu
Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·Y DevauxD Ungureanu-Longrois
Dec 22, 1999·The Proceedings of the Nutrition Society·R D Semba
Jul 16, 2005·Clinical Microbiology Reviews·Eduardo Villamor, Wafaie W Fawzi
Oct 4, 2000·The Journal of Nutrition·W FawziP Nestel
Nov 20, 2012·Journal of Dietary Supplements·Catherine UlbrichtSara Zhou
May 31, 2011·Biochimica Et Biophysica Acta·Elizabeth SpieglerLoredana Quadro

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