PMID: 6164769Jan 1, 1981Paper

Vitamin B 1, B 2 and B 6 deficiency in neurological disorders

Journal of Neurology
H D LangohrG Schroth

Abstract

The activities of the red blood cell enzymes transketolase, glutathione reductase, and glutamic oxaloacetate transaminase were measured with and without in vitro addition of their respective coenzyme components thiamine, riboflavin, and pyridoxine in a group of patients with neurological disorders which may have been caused by malnutrition, intestinal malabsorption, hepatic failure or neoplasms arising outside the nervous system. The incidence of thiamine deficiency was 31%, of riboflavin deficiency 22% and of pyridoxine deficiency 6%. Alcoholics in particular suffered from deficiencies of vitamin B 1, and B 2. There was a correlation of vitamin B 1 and B 2 deficiency and signs of a cerebellar and/or brainstem lesion. The most frequent symptoms in this connection were gait disturbances and oculomotor signs like spontaneous and gaze nystagmus, disturbed eye tracking, diminished optokinetic nystagmus, decreased ability to suppress vestibular nystagmus by fixation. These signs hardly ever occurred in alcoholic patients who showed no deficiency of vitamin B 1, B 2 or B 6. Whenever they do appear, a vitamin B supplementation has to be performed in order to prevent the manifestation of Wernicke's encephalopathy, cerebral or cerebella...Continue Reading

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Citations

Jul 20, 2006·Microbial Cell Factories·Catherine M BurgessDouwe van Sinderen
Oct 9, 2007·Neuroscience and Biobehavioral Reviews·L E FitzpatrickS F Crowe
Aug 28, 2014·Current Opinion in Neurology·Andreea ManoleHenry Houlden
Feb 16, 1987·Klinische Wochenschrift·D ClausE Gmelin
Nov 24, 2018·Journal of Neurology·Thomas JulianPanagiotis Zis
Feb 12, 2011·Journal of the American Animal Hospital Association·Ulrike Michal AltayFrank Steffen

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