Vitamin B-12 and cognition in the elderly

The American Journal of Clinical Nutrition
A David Smith, Helga Refsum

Abstract

Vitamin B-12 deficiency is often associated with cognitive deficits. Here we review evidence that cognition in the elderly may also be adversely affected at concentrations of vitamin B-12 above the traditional cutoffs for deficiency. By using markers such as holotranscobalamin and methylmalonic acid, it has been found that cognition is associated with vitamin B-12 status across the normal range. Possible mediators of this relation include brain atrophy and white matter damage, both of which are associated with low vitamin B-12 status. Intervention trials have not been adequately designed to test whether these associations are causal. Pending the outcome of better trials, it is suggested that the elderly in particular should be encouraged to maintain a good, rather than just an adequate, vitamin B-12 status by dietary means.

References

Jun 1, 1992·The American Journal of Clinical Nutrition·I H Rosenberg, J W Miller
Feb 1, 1992·Journal of the American Geriatrics Society·D C MartinF J Huff
Dec 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·T BottiglieriE H Reynolds
Dec 1, 1988·Journal of the American Geriatrics Society·M Hector, J R Burton
Sep 1, 1996·Journal of Neurochemistry·L D MorrisonS J Kish
Jul 1, 1996·British Medical Bulletin·A D Smith, K A Jobst
Jan 29, 2000·The American Journal of Clinical Nutrition·K L TuckerJ Selhub
Mar 14, 2000·International Journal of Geriatric Psychiatry·R EastleyR S Bucks
Apr 4, 2000·British Medical Bulletin·D G Weir, J M Scott
Apr 30, 2003·The American Journal of Clinical Nutrition·Robert ClarkeJohn M Scott
Jun 18, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·H Refsum, A D Smith
May 25, 2005·Journal of Nutrition for the Elderly·Monica S LewisSally P Stabler
Sep 1, 2005·Journal of Neurology·Magnus-Sebastian VryMatthias Maschke
Aug 19, 2006·Journal of Alzheimer's Disease : JAD·Andrew McCaddon
Dec 13, 2006·The American Journal of Clinical Nutrition·Joshua W Miller
Dec 13, 2006·The American Journal of Clinical Nutrition·Cherie McCrackenUNKNOWN Medical Research Council Cognitive Function and Ageing Study
Jan 9, 2007·The American Journal of Clinical Nutrition·A David Smith
Nov 10, 2007·The American Journal of Clinical Nutrition·Robert ClarkeJohn Grimley Evans
Feb 7, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·J-M KimJ-S Yoon
May 27, 2008·Neurobiology of Aging·M Arfan IkramMonique M B Breteler
Aug 12, 2008·The American Journal of Clinical Nutrition·Helga Refsum, A David Smith
Aug 20, 2008·Food and Nutrition Bulletin·A David Smith
Jan 1, 2009·The American Journal of Clinical Nutrition·Lindsay H Allen
Jan 1, 2009·The American Journal of Clinical Nutrition·Miles D ThompsonJoel G Ray
Jan 15, 2009·The American Journal of Clinical Nutrition·Ralph Green

❮ Previous
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Citations

Nov 11, 2011·European Journal of Clinical Nutrition·K M A SwartP Lips
Dec 12, 2012·Epidemiologic Reviews·Esmée L DoetsLisette C P G M de Groot
Mar 1, 2010·Nutrients·Fiona O'Leary, Samir Samman
Jan 15, 2009·The American Journal of Clinical Nutrition·Ralph Green
Mar 4, 2011·The Journal of Nutrition, Health & Aging·W Chatthanawaree
Mar 23, 2013·The Journal of Nutritional Biochemistry·Natalie ParlettaBarbara J Meyer
Sep 9, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·S SviriP V van Heerden
Jul 19, 2013·Seminars in Dialysis·Catherine M ClaseRachel M Holden
Nov 19, 2011·Journal of Internal Medicine·A David Smith, Helga Refsum
Jun 20, 2014·British Journal of Haematology·Vinod DevaliaUNKNOWN British Committee for Standards in Haematology
Oct 17, 2009·British Journal of Haematology·Edward V Quadros
Mar 22, 2014·Geriatrics & Gerontology International·Sumito Ogawa
Sep 5, 2015·Nutritional Neuroscience·Yen-Hsuan HsuMin-Chien Tu
Dec 3, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Luzia ValentiniHerbert Lochs
Jun 16, 2010·Neuroscience and Biobehavioral Reviews·R A F WeijenbergF Lobbezoo
Dec 29, 2016·Nutrients·Nikita L van der ZwaluwLisette C P G M de Groot
Jan 11, 2014·American Journal of Alzheimer's Disease and Other Dementias·Yadollah Abolfathi MomtazRahimah Ibrahim
Oct 14, 2016·The American Journal of Clinical Nutrition·Hathairat SawaengsriLigi Paul
Aug 11, 2010·Nature Reviews. Neurology·J David Spence
Jan 1, 2009·The American Journal of Clinical Nutrition·Lindsay H Allen
Jun 30, 2010·European Journal of Nutrition·Snorri B RafnssonChittaranjan S Yajnik
Jan 4, 2013·The American Journal of Clinical Nutrition·Tor A StrandNita Bhandari
Dec 1, 2018·The Journal of Nutrition·Lindsay H AllenDaniel J Raiten
Dec 31, 2015·Alzheimer's Research & Therapy·Sanjida AkterMohiuddin Ahmed Bhuiyan
Mar 18, 2016·The American Journal of Clinical Nutrition·A David Smith
Nov 22, 2019·European Journal of Clinical Pharmacology·Yun ZhangYehuan Sun
Oct 9, 2018·Current Medicinal Chemistry·Renata Kozyraki, Olivier Cases
Jan 1, 2009·The American Journal of Clinical Nutrition·Miles D ThompsonJoel G Ray
Feb 26, 2016·The American Journal of Clinical Nutrition·Theresa KöbeAgnes Flöel
Jul 4, 2015·Chemistry : a European Journal·Bernhard Kräutler
Dec 17, 2017·Journal of Pineal Research·Roohi JeelaniHusam M Abu-Soud
May 22, 2019·Current Aging Science·Damanpreet KaurSudhir Kumar
Jul 1, 2017·Nature Reviews. Disease Primers·Ralph GreenChittaranjan Yajnik
Sep 22, 2020·Chemistry : a European Journal·Bernhard Kräutler
Aug 15, 2014·Journal of the American Geriatrics Society·Wilhelmina J Rietsema

❮ Previous
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