Vitamin B metabolism in Plasmodium falciparum as a source of drug targets

Trends in Parasitology
Ingrid B MüllerCarsten Wrenger

Abstract

The malaria parasite Plasmodium falciparum depends primarily on nutrient sources from its human host. Most compounds, such as glucose, purines, amino acids, as well as cofactors and vitamins, are abundantly available in the host cell, and can be readily salvaged by the parasite. However, in some cases the parasite can also synthesize cofactors de novo in reactions that appear to be essential. Importantly, the three biosynthetic pathways that produce vitamins B(1), B(6) and B(9) are absent from the host, but are well established in P. falciparum. This review summarizes and updates the current knowledge of vitamin B de novo synthesis and salvage in P. falciparum and focuses on their potential as targets for drug intervention.

References

Jul 1, 1996·Molecular and Biochemical Parasitology·C M WilsonR V Baylon
Jun 15, 1999·Experimental Parasitology·T Triglia, A F Cowman
Jun 26, 1999·Archives of Microbiology·T P BegleyJ Xi
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·M EhrenshaftM E Daub
Jan 11, 2000·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M TazawaT Nomura
Jul 10, 2001·Journal of Bacteriology·L C BergerB J Berger
Aug 31, 2001·Bioorganic & Medicinal Chemistry Letters·J J ReddickT P Begley
Nov 13, 2001·Molecular and Biochemical Parasitology·C GafanB J Berger
Apr 22, 2003·Nature Structural Biology·Jirundon YuvaniyamaYongyuth Yuthavong
Sep 2, 2003·EMBO Reports·Riccardo Percudani, Alessio Peracchi
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Tahzeeba HossainKarel Schubert
Jun 3, 2004·Nature Reviews. Drug Discovery·David A FidockSolomon Nwaka
Jul 27, 2004·Antimicrobial Agents and Chemotherapy·Rodolphe RoggeroChoukri Ben Mamoun
Jul 29, 2004·Molecular and Biochemical Parasitology·Waraporn KasekarnWorachart Sirawaraporn
Aug 5, 2004·The Journal of Biological Chemistry·Brian G LawhornTadhg P Begley
Aug 7, 2004·Current Opinion in Biotechnology·Martina PohlMichael Müller
Dec 14, 2004·The Journal of Biological Chemistry·Carsten WrengerRolf D Walter
Mar 1, 2005·Pharmacological Reviews·Aric Gregson, Christopher V Plowe
Apr 23, 2005·Acta Tropica·John E Hyde
Jul 26, 2005·Trends in Parasitology·Enrique SalcedoJohn E Hyde
Sep 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Marina Tambasco-StudartTeresa B Fitzpatrick
Sep 15, 2005·Molecular and Biochemical Parasitology·Kristen M MassimineIsabelle Coppens
Dec 13, 2005·The Journal of Biological Chemistry·Martin GengenbacherBarbara Kappes
Dec 27, 2005·Drug Discovery Today·Philip J HajdukChristin Tse
Apr 18, 2006·The Journal of Antimicrobial Chemotherapy·Alexis Nzila
May 6, 2006·Trends in Parasitology·Alexis M NzilaSteve A Ward
May 26, 2006·British Journal of Clinical Pharmacology·Geoffrey Edwards, Giancarlo A Biagini
Jun 23, 2006·PLoS Pathogens·Claire KidgellElizabeth A Winzeler
Dec 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Marco StrohmeierIvo Tews
Feb 3, 2007·Current Drug Targets·Kiaran Kirk, Kevin J Saliba
Feb 6, 2007·Trends in Parasitology·Sylke Müller, Barbara Kappes
May 19, 2007·Molecular and Biochemical Parasitology·Ping WangJohn E Hyde

❮ Previous
Next ❯

Citations

May 9, 2013·Future Medicinal Chemistry·Thales KronenbergerCarsten Wrenger
Mar 19, 2013·Molecular and Biochemical Parasitology·Ingrid B Müller, John E Hyde
Sep 3, 2011·Biochimica Et Biophysica Acta·Barbara KappesPeter Macheroux
Jun 28, 2012·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Sabine ButzloffIngrid B Müller
Apr 7, 2015·Molecular and Biochemical Parasitology·Melanie J ShearsGeoffrey I McFadden
Jun 7, 2015·International Journal of Biological Macromolecules·J YaoC G Whiteley
Nov 8, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Azeem Mehmood ButtYigang Tong
Feb 14, 2014·BioMed Research International·Thales KronenbergerCarsten Wrenger
Feb 6, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mei-Guo SunYun-Xia Cao
Jun 28, 2013·Nature Communications·Xie Wah Audrey ChanKevin J Saliba
Dec 9, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S Balachandar, A Katyal
Jul 31, 2013·Journal of Peptide Science : an Official Publication of the European Peptide Society·Mayra ChamlianVani X Oliveira
Feb 10, 2017·Indian Journal of Nephrology·S MendoncaR Tewari
Nov 27, 2019·The Journal of Biological Chemistry·Aarti KrishnanDominique Soldati-Favre
Jan 30, 2020·Current Drug Targets·Usha K RoutGaurav R Dwivedi
Nov 6, 2014·Acta Crystallographica. Section F, Structural Biology Communications·Thales KronenbergerMatthew R Groves
Dec 10, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·D DerilusS E Massey
Jan 10, 2021·Biochemical and Biophysical Research Communications·Robin M GierseMatthew R Groves
Mar 5, 2020·ACS Infectious Diseases·Soraya S BoschCarsten Wrenger
Jul 31, 2021·Frontiers in Cellular and Infection Microbiology·Angélica Luana C BarraAlessandro S Nascimento
Nov 12, 2021·Chembiochem : a European Journal of Chemical Biology·André F PinaNuno M F S A Cerqueira

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
Carsten WrengerIngrid B Müller
Future Medicinal Chemistry
Thales KronenbergerCarsten Wrenger
Molecular and Biochemical Parasitology
Julia KnöckelCarsten Wrenger
Biochimica Et Biophysica Acta
Tathagata MukherjeeTadhg P Begley
© 2022 Meta ULC. All rights reserved