Vitamin B12-loaded solid lipid nanoparticles as a drug carrier in cancer therapy

Pharmaceutical Development and Technology
Lütfi GençG Güney

Abstract

Nanostructure-mediated drug delivery, a key technology for the realization of nanomedicine, has the potential to improve drug bioavailability, ameliorate release deviation of drug molecules and enable precision drug targeting. Due to their multifunctional properties, solid lipid nanoparticles (SLNs) have received great attention of scientists to find a solution to cancer. Vitamin supplements may contribute to a reduction in the risk of cancer. Vitamin B12 has several characteristics that make it an attractive entity for cancer treatment and possible therapeutic applications. The aim of this study was to produce B12-loaded SLNs (B12-SLNs) and determine the cytotoxic effects of B12-SLNs on H-Ras 5RP7 and NIH/3T3 control cell line. Results obtained by MTT assay, transmission electron and confocal microscopy showed that B12-loaded SLNs are more effective than free vitamin B12 on cancer cells. In addition, characterization studies indicate that while the average diameter of the B12 was about 650 nm, B12-SLNs were about 200 nm and the drug release efficiency of vit. B12 by means of SLNs increased up to 3 h. These observations point to the fact that B12-SLNs could be used as carrier systems due to the therapeutic effects on cancer.

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Citations

Aug 16, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Slavomira DoktorovováEliana B Souto
Jul 6, 2017·Journal of Microencapsulation·Murat DemirbilekCem Akça
Jun 9, 2018·Critical Reviews in Food Science and Nutrition·Elham Assadpour, Seid Mahdi Jafari
Jun 12, 2018·Chembiochem : a European Journal of Chemical Biology·Okoh Adeyi Okoh, Philipp Klahn
Mar 27, 2021·Drug Delivery and Translational Research·Mohamed Dawoud, Randa Abdou
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cristian Mauricio Barreto PinillaAdriano Brandelli

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