PMID: 1201264Nov 1, 1975Paper

Vitamin B12 metabolism in the fruit bat (Rousettus aegyptiacus). The induction of vitamin B12 deficiency and its effect on folate levels

The British Journal of Nutrition
S V van TonderR Green

Abstract

1. Vitamin B12 metabolism was studied in bats of the species Rousettus aegyptiacus, which live on an all-fruit diet in the wild. 2. There was a wide range in values for the serum vitamin B12 concentration of newly captured bats, but bats captured in the early spring had significantly higher mean serum vitamin B12 levels than bats captured in the early autumn. 3. There was an exponential decrease in serum vitamin B12 concentration with time in captivity for bats fed on a vitamin B12-deficient, all-fruit diet; the biological half-life was 80 d in serum, 109 d in liver and 164 d in kidney. 4. The main storage organ for vitamin B12 in the bats was the liver, mean content 1067 ng vitamin B12. After 50 d, injected [57Co]cyanocobalamin had equilibrated with body vitamin B12 stores, and 17% of the retained radioactivity was present in the liver. From these results it was calculated that the total body vitamin B12 content of the bat was c. 6500 ng. 5. The biological half-life of injected [57Co]cyanocobalamin was 70--88 d and the calculated daily requirement was 50--60 ng (0-2 mug/kg body-weight per d). 6. As serum vitamin B12 levels decreased, serum folate levels increased. The erythrocyte folate concentration increased significantly af...Continue Reading

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Citations

Jun 17, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Sarah Cohen-WoodsAnne Farmer
Aug 10, 2007·Harvard Review of Psychiatry·Frances Rachel Frankenburg
Jan 1, 1987·Comparative Biochemistry and Physiology. A, Comparative Physiology·J Metz, J van der Westhuyzen
Oct 11, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Segal M BoazDaniel E Crocker

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