PMID: 6105561Sep 6, 1980Paper

Vitamin B12 regulates folate metabolism by the supply of formate

Lancet
I ChanarinJ Perry

Abstract

Nitrous oxide (N2O) inactivates the B12 coenzyme involved in methionine synthesis and interrupts formation of the folate coenzyme (folate polyglutamate). Normal synthesis of folate polyglutamate is restored in the N2O-treated rat when folate carrying a single carbon unit is supplied at the formate level of oxidation. The activity of the enzyme, formyl synthetase, which links formate to tetrahydrofolate, is increased after exposure to nitrous oxide. Formate is normally derived from the oxidation of methyl groups, methionine being an important source. It is suggested that failure of methionine synthesis leads to a paucity of formate and in turn to inadequate formylation of tetrahydrofolate. Formyltetrahydrofolate is the required substrate for the synthesis of folate polyglutamate, and impairment of this step in turn compromises general folate metabolism.

References

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Citations

Sep 1, 1983·The British Journal of Nutrition·J van der Westhuyzen, J Metz
Aug 1, 1992·The Proceedings of the Nutrition Society·J M Scott
Mar 1, 1990·British Journal of Haematology·R DeaconI Chanarin
Mar 1, 1981·Postgraduate Medical Journal·D SamsonC D Reid
Jun 1, 1984·Journal of Neurochemistry·A M HakimH M Pappius
Apr 1, 1981·British Journal of Haematology·I ChanarinM Lumb
Sep 1, 1982·Critical Reviews in Toxicology·I Chanarin
Jan 1, 1984·Clinical and Laboratory Haematology·J H Matthews, J K Wood
Nov 1, 1983·Scandinavian Journal of Haematology·N A Sourial, L Brown
Oct 1, 1981·Scandinavian Journal of Haematology·R DeaconI Chanarin
Jun 1, 1986·British Journal of Haematology·J H Matthews, S N Wickramasinghe
Nov 1, 1984·Anaesthesia and Intensive Care·J S Willoughby
Nov 1, 1981·Scandinavian Journal of Haematology·G B TennantC A Wardrop
Jan 1, 1985·Biochemical Pharmacology·D G WeirJ M Scott
Sep 1, 1988·Blood Reviews·S N Wickramasinghe, J H Matthews
Sep 16, 1981·Biochemical and Biophysical Research Communications·R DeaconI Chanarin
Dec 31, 1980·Biochemical and Biophysical Research Communications·R DeaconI Chanarin
Jun 1, 1987·Baillière's Clinical Haematology·T E Parry
Sep 1, 1995·Baillière's Clinical Haematology·S N Wickramasinghe
Jan 1, 1985·Critical Reviews in Oncology/hematology·Y KanoF Takaku

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