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Vitamin B6 Addiction in Acute Myeloid Leukemia

Cancer Cell

Jan 15, 2020

Chi-Chao ChenLingbo Zhang

Abstract

Cancer cells rely on altered metabolism to support abnormal proliferation. We performed a CRISPR/Cas9 functional genomic screen targeting metabolic enzymes and identified PDXK-an enzyme that produces pyridoxal phosphate (PLP) from vitamin B6-as an acute myeloid leukemia (AML)-selective ...read more

Mentioned in this Paper

PDXK gene
Vitamin B6 Measurement
Drug Dependence
Vitamin B6 Metabolism Pathway
ODC1 protein, S cerevisiae
Leukemia, Myelocytic, Acute
Screening Generic
Metabolism
Protein KINASE
Pyridoxal Phosphate
40
6
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Vitamin B6 Addiction in Acute Myeloid Leukemia

Cancer Cell

Jan 15, 2020

Chi-Chao ChenLingbo Zhang

PMID: 31935373

DOI: 10.1016/j.ccell.2019.12.002

Abstract

Cancer cells rely on altered metabolism to support abnormal proliferation. We performed a CRISPR/Cas9 functional genomic screen targeting metabolic enzymes and identified PDXK-an enzyme that produces pyridoxal phosphate (PLP) from vitamin B6-as an acute myeloid leukemia (AML)-selective ...read more

Mentioned in this Paper

PDXK gene
Vitamin B6 Measurement
Drug Dependence
Vitamin B6 Metabolism Pathway
ODC1 protein, S cerevisiae
Leukemia, Myelocytic, Acute
Screening Generic
Metabolism
Protein KINASE
Pyridoxal Phosphate
40
6
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
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