Vitamin B6 in plasma and cerebrospinal fluid of children

PloS One
M AlbersenN M Verhoeven-Duif

Abstract

Over the past years, the essential role of vitamin B6 in brain development and functioning has been recognized and genetic metabolic disorders resulting in functional vitamin B6 deficiency have been identified. However, data on B6 vitamers in children are scarce. B6 vitamer concentrations in simultaneously sampled plasma and cerebrospinal fluid (CSF) of 70 children with intellectual disability were determined by ultra performance liquid chromatography-tandem mass spectrometry. For ethical reasons, CSF samples could not be obtained from healthy children. The influence of sex, age, epilepsy and treatment with anti-epileptic drugs, were investigated. The B6 vitamer composition of plasma (pyridoxal phosphate (PLP) > pyridoxic acid > pyridoxal (PL)) differed from that of CSF (PL > PLP > pyridoxic acid > pyridoxamine). Strong correlations were found for B6 vitamers in and between plasma and CSF. Treatment with anti-epileptic drugs resulted in decreased concentrations of PL and PLP in CSF. We provide concentrations of all B6 vitamers in plasma and CSF of children with intellectual disability (±epilepsy), which can be used in the investigation of known and novel disorders associated with vitamin B6 metabolism as well as in monitoring o...Continue Reading

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Citations

Dec 3, 2016·American Journal of Human Genetics·Niklas DarinPeter T Clayton
Jan 4, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tomoyuki AkiyamaKatsuhiro Kobayashi
Jun 28, 2016·Journal of Inherited Metabolic Disease·Déborah MathisBarbara Plecko
Jan 24, 2019·Journal of Inherited Metabolic Disease·Matthew P WilsonPeter T Clayton
Jul 2, 2019·Human Molecular Genetics·Wanhao ChiXiaoxi Zhuang
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Nov 25, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Jolita CiapaiteNanda M Verhoeven-Duif
Aug 6, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tomoyuki AkiyamaKatsuhiro Kobayashi

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