Vitamin C Activates Osteoblastogenesis and Inhibits Osteoclastogenesis via Wnt/β-Catenin/ATF4 Signaling Pathways

Nutrients
Hyeon Kyeong ChoiJeung Hee An

Abstract

This study evaluated the effects of vitamin C on osteogenic differentiation and osteoclast formation, and the effects of vitamin C concentration on bone microstructure in ovariectomized (OVX) Wistar rats. Micro-computed tomography analysis revealed the recovery of bone mineral density and bone separation in OVX rats treated with vitamin C. Histomorphometrical analysis revealed improvements in the number of osteoblasts, osteoclasts, and osteocytes; the osteoblast and osteoclast surface per bone surface; and bone volume in vitamin C-treated OVX rats. The vitamin C-treated group additionally displayed an increase in the expression of osteoblast differentiation genes, including bone morphogenetic protein-2, small mothers against decapentaplegic 1/5/8, runt-related transcription factor 2, osteocalcin, and type I collagen. Vitamin C reduced the expression of osteoclast differentiation genes, such as receptor activator of nuclear factor kappa-B, receptor activator of nuclear factor kappa-B ligand, tartrate-resistant acid phosphatase, and cathepsin K. This study is the first to show that vitamin C can inhibit osteoporosis by promoting osteoblast formation and blocking osteoclastogenesis through the activation of wingless-type MMTV inte...Continue Reading

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Citations

Aug 14, 2020·Nutrients·Olga BrzezińskaKonrad Walczak
May 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcela Martín-Del-CampoLuis Rojo
Oct 22, 2020·Nutrients·Moriah P BellissimoJessica A Alvarez
Dec 11, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Bennett OakesFrank A Petrigliano
Jan 24, 2021·International Journal of Biological Macromolecules·Zhuo HanZekun Guo
Nov 27, 2020·Colloids and Surfaces. B, Biointerfaces·Banafsheh SafariSoodabeh Davaran
Mar 9, 2021·Drug Discovery Today·Xin LiLing Ye

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Methods Mentioned

BETA
Assay
PCR
electrophoresis
protein assay

Software Mentioned

Inveon acquisition workplace
SPSS
[UNK]

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