PMID: 8951736Dec 1, 1996Paper

Vitamin C depletion is associated with alterations in blood histamine and plasma free carnitine in adults

Journal of the American College of Nutrition
C S JohnstonC Corte

Abstract

The purpose of this study was to determine whether carnitine metabolism or histamine degradation would be useful parameters for investigating the optimal requirement for vitamin C. Twenty-two non-scorbutic subjects with subnormal vitamin C status (plasma vitamin C < 28 mumol/L) were placed on a metabolic diet low in vitamin C for 3 weeks and repleted with graded doses of vitamin C: 10, 30 and 60 mg vitamin C daily (group 1) or 10,125 and 250 mg vitamin C daily (group 2) for weeks 1, 2 and 3, respectively. Fasting blood samples were collected weekly and analyzed for plasma vitamin C, plasma free carnitine and blood histamine. Group 1 subjects remained in a subnormal vitamin C state throughout the 3-week study, and blood histamine and plasma free carnitine were not impacted by the experimental treatment. Plasma vitamin C in group 2 subjects rose significantly during the study, and these subjects finished the study with an ample vitamin C status indicative of vitamin C intakes above the recommended dietary allowance. Both blood histamine and plasma free carnitine were inversely related to vitamin C status in group 2 subjects. These data indicate that blood histamine and plasma free carnitine are altered in individuals with subnorm...Continue Reading

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Citations

May 15, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Alexander F HagelMartin Raithel
Jul 16, 1999·Journal of the American Dietetic Association·C S Johnston, C Corte
Nov 13, 2004·The Journal of Nutritional Biochemistry·C S Johnston, C Corte
Aug 26, 1998·Journal of the American College of Nutrition·C S Johnston, L L Thompson
Apr 29, 1998·Journal of American College Health : J of ACH·C S JohnstonC Corte
Jan 1, 2014·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Harri Hemilä
Apr 11, 2009·Pediatric Clinics of North America·Alex V Levin
Oct 11, 2015·Respiratory Physiology & Neurobiology·Stephanie P KurtiCraig A Harms
Nov 23, 2005·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Timothy J HalliganTimothy B Skelton
Jan 27, 2015·Psychosomatics·Thomas M Brown
Sep 26, 2003·The Proceedings of the Nutrition Society·Karen Munday
Aug 31, 1999·The Proceedings of the Nutrition Society·I F Benzie
Jun 3, 2017·Nutrients·Camilo G SotomayorStephan J L Bakker
Jun 29, 2018·The Journal of International Medical Research·Claudia VollbrachtAlexander F Hagel
Nov 4, 2017·Nutrients·Anitra C Carr, Silvia Maggini
Jun 24, 2020·Journal of Clinical Medicine·Camilo G SotomayorStephan J L Bakker

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