Vitamin C improves the effect of a new nitric oxide donor on the vascular smooth muscle from renal hypertensive rats

Nitric Oxide : Biology and Chemistry
G J RodriguesLusiane M Bendhack

Abstract

Impaired relaxation induced by the new nitric oxide (NO) donor [Ru(NH.NHq)(terpy)NO(+)](3+) (TERPY) has been observed in the aortic rings from renal hypertensive rats (2K-1C). An increased production of reactive oxygen species (ROS) in the aortas from 2K-1C rats are capable of reducing NO bioavailability. Therefore, this study aimed at investigating the effects of an antioxidant (vitamin C) on the relaxant effect of NO released from TERPY on the 2K-1C rat aorta. As for vascular reactivity, the potency of TERPY is greater in the control rats (2K) than in 2K-1C whereas the maximum relaxation (ME) is not significantly different between the 2K and 2K-1C rat aortas. The relaxation of TERPY is potentiated only in the 2K-1C aortic ring treated with vitamin C. TERPY has a lower effect in decreasing cytosolic Ca(2+) concentration ([Ca(2+)]c) in vascular smooth muscle cells (VSMCs) from 2K-1C rats. This effect is also potentiated in 2K-1C aortic cells treated with vitamin C, but it is not altered in 2K cells. The basal cytosolic NO concentration ([NO]c) is lower in 2K-1C than in 2K cells, and the bioavailability of the NO released from TERPY is larger in 2K than in 2K-1C VSMCs. The superoxide radical concentration ([O(2)(*-)]) is higher ...Continue Reading

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Citations

Jun 21, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Michele PauloLusiane Maria Bendhack
Sep 24, 2013·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Leônidas das Graças Mendes-JuniorValdir de Andrade Braga
Apr 9, 2014·Journal of Chemical Biology·Bruno R SilvaLusiane M Bendhack
Jun 20, 2014·Future Medicinal Chemistry·Michele PauloLusiane M Bendhack
May 29, 2012·Journal of Cardiovascular Pharmacology·Gerson J RodriguesLusiane M Bendhack
Jul 9, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Renata Galvão de LimaLusiane Maria Bendhack
Dec 20, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Michele PauloLusiane M Bendhack
Dec 20, 2011·Nitric Oxide : Biology and Chemistry·Elia TfouniDouglas Wagner Franco
May 25, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Patrícia F S CastroMatheus L Rocha
Nov 12, 2009·European Journal of Pharmacology·Gerson J RodriguesLusiane M Bendhack
Apr 14, 2009·Nitric Oxide : Biology and Chemistry·Anderson Rodrigo Moraes de OliveiraPierina Sueli Bonato
Mar 3, 2009·Free Radical Biology & Medicine·Michele M CastroJose E Tanus-Santos
Dec 31, 2008·Nitric Oxide : Biology and Chemistry·Cristiane Masetto de GaitaniLusiane M Bendhack
Jul 19, 2008·European Journal of Pharmacology·Marcio L L MartinezJose E Tanus-Santos
Feb 5, 2010·British Journal of Pharmacology·Paulo M M GuedesJoão Santana Silva
Aug 24, 2013·Nitric Oxide : Biology and Chemistry·Alice V AraújoLusiane M Bendhack
Sep 3, 2013·Journal of the American College of Cardiology·Peter A McCullough, Krittapoom Akrawinthawong
Jan 17, 2012·Nitric Oxide : Biology and Chemistry·Felipe C MunhozCristina Antoniali
Nov 11, 2014·Journal of Cardiovascular Pharmacology·Gerson Jhonatan RodriguesLusiane Maria Bendhack
Sep 6, 2012·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Juan M MuriasEarl G Noble
Mar 25, 2017·Expert Opinion on Therapeutic Targets·Lucas C PinheiroMichele M Castro
Jul 15, 2011·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A C PereiraL M Bendhack
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May 20, 2020·Current Pharmaceutical Design·Michele PauloLusiane M Bendhack
Mar 19, 2021·Lasers in Medical Science·Luis Henrique Oliveira de MoraesGerson Jhonatan Rodrigues
Aug 17, 2018·Journal of Molecular and Cellular Cardiology·T D PaulaL M Bendhack

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