Vitamin C in Health and Disease: Its Role in the Metabolism of Cells and Redox State in the Brain

Frontiers in Physiology
Rodrigo Figueroa-Méndez, Selva Rivas-Arancibia

Abstract

Ever since Linus Pauling published his studies, the effects of vitamin C have been surrounded by contradictory results. This may be because its effects depend on a number of factors such as the redox state of the body, the dose used, and also on the tissue metabolism. This review deals with vitamin C pharmacokinetics and its participation in neurophysiological processes, as well as its role in the maintenance of redox balance. The distribution and the concentration of vitamin C in the organs depend on the ascorbate requirements of each and on the tissue distribution of sodium-dependent vitamin C transporter 1 and 2 (SVCT1 and SVCT2). This determines the specific distribution pattern of vitamin C in the body. Vitamin C is involved in the physiology of the nervous system, including the support and the structure of the neurons, the processes of differentiation, maturation, and neuronal survival; the synthesis of catecholamine, and the modulation of neurotransmission. This antioxidant interacts with self-recycling mechanisms, including its participation in the endogenous antioxidant system. We conclude that the pharmacokinetic properties of ascorbate are related to the redox state and its functions and effects in tissues.

References

Sep 30, 1975·Annals of the New York Academy of Sciences·B H BielskiP C Chan
Sep 30, 1975·Annals of the New York Academy of Sciences·B M TolbertE M Baker
Dec 1, 1991·The American Journal of Clinical Nutrition·M Nishikimi, K Yagi
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B FreiB N Ames
May 11, 1981·Brain Research·I N MeffordR N Adams
Dec 1, 1995·The American Journal of Clinical Nutrition·E NikiN Gotoh
Aug 1, 1994·Journal of Bioenergetics and Biomembranes·W W Wells, D P Xu
Feb 1, 1994·European Journal of Biochemistry·M Mueckler
Dec 1, 1993·The American Journal of Physiology·P S Jackson, K Strange
Jan 1, 1993·Brain Research. Brain Research Reviews·R A Grünewald
Oct 1, 1995·Kidney International·K Strange, P S Jackson
Mar 1, 1996·Journal of Neurochemistry·R SiushansianJ X Wilson
Feb 12, 1998·The Journal of Clinical Investigation·D B AgusD W Golde
Apr 29, 1998·Nature·I D PodmoreJ Lunec
Sep 29, 1998·Nature·M LevineY Wang
Oct 15, 1998·Alzheimer Disease and Associated Disorders·M C MorrisD A Evans
May 20, 1999·Nature·H TsukaguchiM A Hediger
May 25, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J M May
May 24, 2000·The Journal of Biological Chemistry·H DoegeH G Joost
Jul 6, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·F PuskasA Perl
Sep 30, 2000·European Journal of Biochemistry·E S Arnér, A Holmgren
Jun 27, 2001·Free Radical Biology & Medicine·J M MayC E Cobb
Sep 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·S KaranthS M McCann
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·J HuangE S Connolly
Nov 24, 2001·Respiration Physiology·M Erecińska, I A Silver
Jan 5, 2002·Physiological Reviews·Wulf Dröge
Sep 11, 2002·FEBS Letters·John X Wilson
Feb 1, 2003·Archives of Biochemistry and Biophysics·Alexander J MichelsTory M Hagen
Feb 6, 2003·Journal of the American College of Nutrition·Sebastian J PadayattyMark Levine
Jul 2, 2003·Journal of Neuroscience Research·Ji-Yeon LeeSang-Hun Lee
Jul 1, 1957·Archives of Biochemistry and Biophysics·A P GROLLMAN, A L LEHNINGER
Apr 21, 1961·Annals of the New York Academy of Sciences·I B CHATTERJEEB C GUHA
Oct 28, 2003·Journal of Pharmacological Sciences·Milind Parle, Dinesh Dhingra
Apr 1, 2004·European Journal of Clinical Nutrition·A MühlhöferH K Biesalski

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Citations

Feb 24, 2016·Frontiers in Pharmacology·Valeria ContiAmelia Filippelli
Jan 9, 2017·Free Radical Biology & Medicine·Adele RomanoSilvana Gaetani
Nov 27, 2016·Free Radical Biology & Medicine·Wojciech ŁuczajElżbieta Skrzydlewska
Jul 13, 2017·Antioxidants & Redox Signaling·Orazio CantoniMara Fiorani
Apr 4, 2018·Chemistry : a European Journal·Amandine Conte-DabanChristelle Hureau
Apr 4, 2018·Journal of Bacteriology·Hiroshi KanazawaNaoki Takaya
Feb 23, 2017·World Journal of Critical Care Medicine·Bassem M MohammedRamesh Natarajan
Dec 12, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Yawen ZhangFang Zhou
Nov 16, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Sebastian DamsManfred Lamprecht
Dec 17, 2017·Oncotarget·Camila C PortugalJoão B Relvas
Jun 18, 2020·Proceedings. Biological Sciences·Stefania CasagrandeScott R McWilliams
Jul 21, 2020·Critical Reviews in Food Science and Nutrition·Maria Αntoniadou, Theodoros Varzakas
Jan 10, 2018·Journal of Anatomy·P MarcosM M Arroyo-Jiménez
Apr 3, 2019·Nutrients·Harri Hemilä, Elizabeth Chalker
Jul 9, 2020·Journal of Inflammation Research·Kritsanawan Sae-KhowDirekrit Chiewchengchol
Apr 11, 2018·Oxidative Medicine and Cellular Longevity·Nicholas E BuglakEdward S M Bahnson
Apr 28, 2020·The Cochrane Database of Systematic Reviews·Zahra Ali PadhaniZulfiqar A Bhutta
Feb 23, 2020·Frontiers in Pediatrics·Christel ChalouhiVéronique Abadie
Apr 20, 2019·Frontiers in Aging Neuroscience·Nikolaj TravicaAndrew Pipingas
Jun 27, 2018·Antimicrobial Agents and Chemotherapy·Luís Cláudio Lima de JesusSilma Regina Ferreira Pereira
Oct 28, 2020·Antioxidants·Tsu-Kung LinYao-Chung Chuang
Feb 15, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Ahmad SalimiNahid Etefaghi
Oct 29, 2020·Nutrition·Khulud Diab ShehadeYonatan Yeshayahu
Dec 30, 2020·Antioxidants·Faraz Ahmad, Ping Liu
Feb 3, 2021·Nutrients·Mary BrauchlaColin D Rehm
Oct 16, 2020·Chemistry : a European Journal·Charlène EsmieuChristelle Hureau
Mar 11, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Bruno M MoukettePaulo J Oliveira
Aug 24, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Dilshan S HarischandraAnumantha G Kanthasamy
Apr 4, 2021·Antioxidants·Ana Patricia Duarte-JuradoHumberto Rodriguez-Rocha
Jun 6, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Haripriya Kuchi BhotlaBalamuralikrishnan Balasubramanian
Jun 18, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Min Cheol ChangSoyoung Kwak
Jul 3, 2021·International Journal of Molecular Sciences·Rosaria NotarialeCaterina Manna

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