PMID: 11903736Mar 21, 2002Paper

Vitamin C inhibits corpus gastritis in Helicobacter pylori-infected patients during acid-suppressive therapy

Journal of Gastroenterology and Hepatology
M YoshinagaH Nawata

Abstract

Previous studies have shown that gastric acid suppression worsens corpus gastritis in Helicobacter pylori (H. pylori)-positive patients. We evaluated the effect of acid-suppressive therapy and vitamin C on H. pylori-associated gastritis. Forty patients with reflux esophagitis were divided into three groups by the status of H. pylori and therapy: group A (n=15), H. pylori (+) and omeprazole 20 mg; group B (n=15), H. pylori (+) and omeprazole 20 mg + vitamin C 1200 mg; and group C (n=10), H. pylori (-) and omeprazole 20 mg. In all three groups, the mucosal interleukin (IL)-8 contents, H. pylori colonization density, neutrophil infiltration in the corpus, and serum gastrin were evaluated at entry and 2 weeks after starting therapy; in group B, serum vitamin C levels were also measured. In group A, the IL-8 contents and the degree of neutrophil infiltration during therapy exceeded those at entry, whereas in groups B and C, these values did not change significantly with treatment. Helicobacter pylori colonization density during therapy was similar to that at entry in all three groups. The serum gastrin (in all groups) and vitamin C levels (in group B) during therapy exceeded those at entry. Potent acid suppression worsens H. pylori-...Continue Reading

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Citations

May 1, 2012·Digestive Diseases and Sciences·Anupam Aditi, David Y Graham
Jan 31, 2014·Journal of Nutritional Science and Vitaminology·Kazumasa MiyakeChoitsu Sakamoto
Nov 15, 2011·Biochimica Et Biophysica Acta·Hannelien VerbekeStruyf Sofie
Aug 12, 2005·European Journal of Gastroenterology & Hepatology·Mayra M Kamiji, Ricardo B de Oliveira

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