Vitamin C metabolism and atopic allergy.

Clinical Allergy
C W WilsonK Watters

Abstract

The procedure for carrying out the Leucocyte Ascorbic Acid Uptake Direct Antigen Challenge Test (LAADACT) is described. Leucocytes from normal individuals, when incubated in a buffered medium containing ascorbic acid, increase their ascorbic acid concentration by about 80%. When leucocytes from atopic individuals are incubated in a medium containing the antigen to which they are sensitive, as shown by positive skin tests, the leucocyte uptake of ascorbic acid is significantly reduced. Addition of antigen, to which atopic or normal individuals are not sensitive, to the incubation mixture does not reduce leucocyte ascorbic acid uptake. Measurement of ascorbic acid uptake into leucocytes is a relatively simple, routine, laboratory procedure. The LAADACT, therefore, provides a quick and accurate blood test for diagnosing sensitivity to specific antigens, and measuring relative antigenic sensitivities. The underlying mechanism of the LAADACT is discussed.

References

Nov 21, 1970·Lancet·H S Kaufman, J R Hobbs
Dec 1, 1974·The Proceedings of the Nutrition Society·C W Wilson
May 30, 1970·British Medical Journal·E S Assem, M K McAllen
Jul 4, 1970·Nature·J A Edgar
Apr 1, 1973·The Journal of Allergy and Clinical Immunology·P Steinberg, P S Norman
Jun 30, 1965·Annals of the New York Academy of Sciences·W J IrvineA W Williams
Aug 1, 1964·The Journal of Experimental Medicine·P G QUIE, J G HIRSCH

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Citations

Nov 1, 1973·Journal of Clinical Pharmacology·H S LohC W Wilson

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