Vitamin C supplementation ameliorates the adverse effects of nicotine on placental hemodynamics and histology in nonhuman primates

American Journal of Obstetrics and Gynecology
Jamie O LoAntonio E Frias

Abstract

We previously demonstrated that prenatal nicotine exposure decreases neonatal pulmonary function in nonhuman primates, and maternal vitamin C supplementation attenuates these deleterious effects. However, the effect of nicotine on placental perfusion and development is not fully understood. This study utilizes noninvasive imaging techniques and histological analysis in a nonhuman primate model to test the hypothesis that prenatal nicotine exposure adversely effects placental hemodynamics and development but is ameliorated by vitamin C. Time-mated macaques (n = 27) were divided into 4 treatment groups: control (n = 5), nicotine only (n = 4), vitamin C only (n = 9), and nicotine plus vitamin C (n = 9). Nicotine animals received 2 mg/kg per day of nicotine bitartrate (approximately 0.7 mg/kg per day free nicotine levels in pregnant human smokers) from days 26 to 160 (term, 168 days). Vitamin C groups received ascorbic acid at 50, 100, or 250 mg/kg per day with or without nicotine. All underwent placental dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) at 135-140 days and Doppler ultrasound at 155 days to measure uterine artery and umbilical vein velocimetry and diameter to calculate uterine artery volume blood flow ...Continue Reading

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Citations

Jan 25, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Michael K WongDaniel B Hardy
Jun 6, 2016·Reproductive Toxicology·Hadas Ganer HermanMichal Kovo
Mar 2, 2016·American Journal of Obstetrics and Gynecology·Victoria H J RobertsAntonio E Frias
Oct 4, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Michael K WongAlison C Holloway
Jan 19, 2018·Nature Communications·Alec J HirschDaniel N Streblow
Feb 6, 2020·Prenatal Diagnosis·Melissa A Suter, Kjersti M Aagaard
May 23, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·Leah YiehDmitry Dukhovny
Aug 9, 2021·American Journal of Obstetrics and Gynecology·Jamie O LoChristopher D Kroenke

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