Vitamin C supplementation decreases insulin glycation and improves glucose homeostasis in obese hyperglycemic (ob/ob) mice

Metabolism: Clinical and Experimental
Yasser H A Abdel-WahabPeter R Flatt

Abstract

The effects of dietary vitamin C supplementation on glucose homeostasis and insulin glycation were examined in adult lean and obese hyperglycemic (ob/ob) mice. In lean mice, supplementation of the drinking water with vitamin C (25 g/L) for 14 days did not affect food intake, fluid intake, glycated hemoglobin, plasma glucose, or plasma insulin concentrations. Total pancreatic insulin content and the percentage of glycated pancreatic insulin were also similar to control lean mice. In ob/ob mice, vitamin C supplementation caused significant reductions by 26% to 48% in food intake and fluid intake, glycated hemoglobin, plasma glucose, and insulin concentrations compared with untreated control ob/ob mice. The total insulin content and the extent of insulin glycation in the pancreas of ob/ob mice were also significantly decreased by 42% to 45% after vitamin C supplementation. This change was accompanied by a significant 80% decrease in the percentage of glycated insulin in the circulation of vitamin C-supplemented ob/ob mice. These data demonstrate that vitamin C supplementation can decrease insulin glycation and ameliorate aspects of the obesity-diabetes syndrome in ob/ob mice.

Citations

Nov 26, 2008·Journal of Basic and Clinical Physiology and Pharmacology·Swati N TikareKusal K Das
Jun 26, 2009·Cellular and Molecular Life Sciences : CMLS·Robert Root-Bernstein, Jessica Vonck
Jan 22, 2011·Pathophysiology of Haemostasis and Thrombosis·Saime BatırelNesrin Emekli
Apr 5, 2014·European Journal of Nutrition·Britt TranbergJens Lykkesfeldt
Mar 30, 2011·Journal of the Science of Food and Agriculture·Cheng-chin HsuMei-chin Yin
Oct 24, 2009·The British Journal of Nutrition·Rashmi Santosh Tupe, Vaishali Vilas Agte
Jan 1, 2014·Journal of Nutritional Science and Vitaminology·Diego Fernando Garcia-DiazJose Alfredo Martinez
Aug 28, 2015·European Journal of Clinical Investigation·Mehrnoosh KhodaeianBagher Larijani
Mar 29, 2012·Experimental Biology and Medicine·Diego F Garcia-DiazJ Alfredo Martinez
Nov 5, 2010·Diabetes, Obesity & Metabolism·A Volchuk, D Ron
Oct 5, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Hyunghee LeeMichung Yoon
Oct 18, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·M Pilar ValdecantosJ Alfredo Martínez
Jun 16, 2021·Molecular Nutrition & Food Research·Yangmian YuanLing Zheng
Jun 18, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Yanqi MaSongbo Fu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.