PMID: 9430612Jan 31, 1998Paper

Vitamin C supplementation restores the impaired vitamin E status of guinea pigs fed oxidized frying oil

The Journal of Nutrition
J F Liu, Y W Lee

Abstract

To investigate the effect of dietary oxidized frying oil (OFO) on tissue retention of vitamin C, and to explore the effect of vitamin C supplementation on tissue vitamin E concentrations and lipid peroxidation, male weanling guinea pigs were divided into four groups. Guinea pigs were fed 15% OFO diets supplemented with vitamin C at 300, 600 or 1500 mg/kg diet. Control animals were fed a diet containing 15% fresh untreated soybean oil with 300 mg/kg of vitamin C. After 60 d of feeding, body weight gain, food intake, feed efficiency and plasma triglyceride concentration were significantly lower in guinea pigs fed OFO diets than in controls (P < 0.05). However, plasma cholesterol concentration was highest in guinea pigs fed the OFO diet supplemented with 300 mg/kg vitamin C. Increasing vitamin C in OFO diets significantly reduced plasma cholesterol concentration. Plasma and tissue vitamins C and E concentrations were significantly lower in the OFO-fed guinea pigs receiving 300 mg/kg vitamin C than in controls. Greater levels of supplemental vitamin C increased tissue vitamins C and E. Guinea pigs fed OFO diets had significantly higher tissue levels of thiobarbituric acid reactive substances (TBARS) (P < 0.05) than controls. Our re...Continue Reading

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Citations

Aug 9, 2002·The Journal of International Medical Research·B SarisözenO F Bilgen
Mar 28, 2007·Nutrition Journal·Jesse BertinatoMary R L'Abbé
Jan 6, 2011·Molecular Nutrition & Food Research·Robert Ringseis, Klaus Eder
Sep 1, 2000·The British Journal of Nutrition·I M HamiltonJ J Strain
Feb 24, 2001·The Journal of Nutrition·M L Fernandez
Jul 26, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Joshua A BeckmanMark A Creager
Mar 15, 2003·The Journal of International Medical Research·K DurakC Ozturk
Mar 27, 2007·The British Journal of Nutrition·Sebastian LuciKlaus Eder
Oct 18, 2020·Antioxidants·Rhoda OloweTawfeeq Shekh-Ahmad
Oct 31, 2003·Molecular Aspects of Medicine·A AzziJ-M Zingg

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