Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP): Rationale, design, and methods of a randomized, controlled trial of vitamin C supplementation in pregnancy for the primary prevention of effects of in utero tobacco smoke exposure on infant lung function and respiratory health

Contemporary Clinical Trials
Cindy T McEvoyCynthia D Morris

Abstract

Despite strong anti-smoking efforts, at least 12% of American women cannot quit smoking when pregnant resulting in >450,000 smoke-exposed infants born yearly. Smoking during pregnancy is the largest preventable cause of childhood respiratory illness including wheezing and asthma. Recent studies have shown a protective effect of vitamin C supplementation on the lung function of offspring exposed to in utero smoke in a non-human primate model and an initial human trial. Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) is a randomized, double-blind, placebo-controlled trial to evaluate pulmonary function at 3months of age in infants delivered to pregnant smokers randomized to 500mg/day of vitamin C versus placebo during pregnancy. Secondary aims evaluate the incidence of wheezing through 12months and pulmonary function testing at 12months of age. Women are randomized between 13 and 23weeks gestation from clinical sites in Portland, Oregon at Oregon Health & Science University and PeaceHealth Southwest Medical Center and in Indianapolis, Indiana at Indiana University and Wishard Hospital. Vitamin C supplementation occurs from randomization to delivery. Monthly contact with participants and m...Continue Reading

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Citations

May 26, 2018·JAMA : the Journal of the American Medical Association·Anna Maria HibbsCurtis Tatsuoka
Aug 2, 2018·The Journal of Physiology·Kara Goss
Dec 14, 2018·American Journal of Respiratory and Critical Care Medicine·Cindy T McEvoyCynthia D Morris
Aug 23, 2018·Internal Medicine Journal·Michael Kennedy
Feb 6, 2020·Prenatal Diagnosis·Melissa A Suter, Kjersti M Aagaard
Oct 10, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ettore LignelliRory E Morty
Apr 4, 2021·International Journal of Environmental Research and Public Health·Ashley SchermanCindy T McEvoy
Dec 17, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Vikas MaharshiArvind Kumar

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