Vitamin D and 1,25-dihydroxyvitamin D3 as modulators in the immune system

The Journal of Steroid Biochemistry and Molecular Biology
Chantal MathieuLut Overbergh

Abstract

Treatment from weaning until old age with 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3)) prevents diabetes in NOD mice. It is mainly through its actions on dendritic cells (DCs), that 1,25(OH)(2)D(3) changes the function of potentially autoreactive T lymphocytes. In contrast, early life treatment (from 3 to 70 days of age) of NOD mice with vitamin D or 1,25(OH)(2)D(3) did not influence final diabetes incidence at 200 days of age. Also in spontaneous diabetic BB rats, diabetes could not be prevented by early life treatment (from 3 to 50 days of age) with vitamin D (1000 IU per day) or 1,25(OH)(2)D(3) (0.2 microg/kg per day or 1 microg/kg per 2 days). However, when NOD mice were made vitamin D deficient in early life (until 100 days of age), diabetes onset occurred earlier and final incidence was increased. These data further support a role for vitamin D and its metabolites in the pathogenesis of type 1 diabetes in NOD mice.

References

Nov 1, 1992·Diabetes·C MathieuR Bouillon
Jun 1, 1997·Transplantation Proceedings·H J HahnR Bouillon
Jan 6, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M Feili-Hariri, P A Morel
Mar 16, 2001·The Journal of Endocrinology·R RiachyF Pattou
May 11, 2002·Nutrition Reviews·Susan Harris
Sep 17, 2002·The Proceedings of the Nutrition Society·Evelyne van EttenChantal Mathieu

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Citations

Jun 23, 2005·Diabetologia·C MathieuR Bouillon
Jan 5, 2007·Reviews in Endocrine & Metabolic Disorders·Hui Peng, William Hagopian
Oct 1, 2013·Sleep Medicine Reviews·David E McCartyAndrew A Marino
May 22, 2013·The Proceedings of the Nutrition Society·Philip C Calder
Jun 27, 2009·Nutrition Research Reviews·Dorothy Teegarden, Shawn S Donkin
Oct 4, 2005·The British Journal of Nutrition·Kirsi LaitinenErika Isolauri
Jun 21, 2012·Menopause : the Journal of the North American Menopause Society·Peter F SchnatzSusan E Appt
Aug 30, 2008·Journal of Gastroenterology and Hepatology·Nosratollah NaderiMohammad R Zali
Dec 5, 2008·Nutrition Reviews·Michael F Holick
Nov 16, 2013·Italian Journal of Pediatrics·Seham F A AzabAsmaa M H Esh
Aug 13, 2008·Endocrine Reviews·Roger BouillonMarie Demay
Jul 28, 2010·Experimental Biology and Medicine·Danny BruceMargherita T Cantorna
Oct 17, 2009·Cancer Investigation·Jennifer L KellySusan G Fisher
Oct 23, 2012·Nutrition Research·Tatiana F S TeixeiraMaria do Carmo G Peluzio
Jun 15, 2011·Molecular and Cellular Endocrinology·James P KesbyJohn J McGrath
Jul 16, 2008·Molecular Aspects of Medicine·Femke BaekeChantal Mathieu
Jun 20, 2008·Molecular Aspects of Medicine·Margherita T CantornaDanny Bruce
Nov 23, 2006·Diabetes Research and Clinical Practice·Annapaula GiuliettiChantal Mathieu
Dec 11, 2008·Pediatric Diabetes·Jannet SvenssonUNKNOWN Danish Childhood Diabetes Registry
Jan 30, 2013·Molecular Carcinogenesis·Natalie NemazannikovaCrispin R Dass
May 31, 2011·Actas dermo-sifiliográficas·Y GilaberteE Nagore
Jul 6, 2005·Trends in Endocrinology and Metabolism : TEM·Chantal Mathieu, Klaus Badenhoop
Aug 29, 2012·Dermato-endocrinology·Abha Singh, Diane L Kamen
Nov 3, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Asta JuzenieneJohan Moan
Jun 9, 2009·Psychoneuroendocrinology·D W EylesT H J Burne
Jul 25, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Mehmet DemirMehmet Melek
Jul 7, 2011·European Journal of Clinical Nutrition·R S MasonC Gordon-Thomson
Mar 9, 2007·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·M NorvalJ C van der Leun
Nov 13, 2009·Pediatric Diabetes·Vibhor V BorkarA K Bhalla
Jun 24, 2005·Photochemistry and Photobiology·A-L PonsonbyI A F van der Mei
Mar 2, 2006·American Journal of Physiology. Endocrinology and Metabolism·Jun SunYan Chun Li
Jun 24, 2008·Critical Reviews in Clinical Laboratory Sciences·Samantha KimballReinhold Vieth
Jun 21, 2014·Biologie aujourd'hui·François FéronPatrick Decherchi
Oct 5, 2006·Photochemistry and Photobiology·Mary Norval
Sep 12, 2017·Brain Sciences·Anna CieślińskaHuub F J Savelkoul
Oct 29, 2020·Dermatologic Therapy·Maha Fathy ElmasryHeba Ahmed Abdelkader

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