Vitamin D and Alzheimer's Disease: Neurocognition to Therapeutics

International Journal of Alzheimer's Disease
Anindita BanerjeeSasanka Chakrabarti

Abstract

Alzheimer's disease (AD), the major cause of dementia worldwide, is characterized by progressive loss of memory and cognition. The sporadic form of AD accounts for nearly 90% of the patients developing this disease. The last century has witnessed significant research to identify various mechanisms and risk factors contributing to the complex etiopathogenesis of AD by analyzing postmortem AD brains and experimenting with animal and cell culture based models. However, the treatment strategies, as of now, are only symptomatic. Accumulating evidences suggested a significant association between vitamin D deficiency, dementia, and AD. This review encompasses the beneficial role of vitamin D in neurocognition and optimal brain health along with epidemiological evidence of the high prevalence of hypovitaminosis D among aged and AD population. Moreover, disrupted signaling, altered utilization of vitamin D, and polymorphisms of several related genes including vitamin D receptor (VDR) also predispose to AD or AD-like neurodegeneration. This review explores the relationship between this gene-environmental influence and long term vitamin D deficiency as a risk factor for development of sporadic AD along with the role and rationale of thera...Continue Reading

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Citations

Oct 30, 2016·International Journal of Molecular Sciences·Marcus O W GrimmTobias Hartmann
Nov 28, 2017·Diabetology & Metabolic Syndrome·Parvin BabaeiBahram Soltani Tehrani
Aug 2, 2018·International Journal of Molecular Sciences·Rita MorettiPaola Caruso
Jun 6, 2017·Aging and Disease·Anindita BanerjeeSasanka Chakrabarti
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Dec 20, 2017·International Journal of Molecular Sciences·Marcus O W GrimmTobias Hartmann
Dec 11, 2020·Cellular and Molecular Neurobiology·Mayukha BathiniKrishna Kishore Mahato
Apr 4, 2021·Brain Sciences·Giulia BivonaMarcello Ciaccio
May 1, 2021·Nutrients·Nicholas G NorwitzRichard S Isaacson
Jul 13, 2021·Journal of Medicinal Chemistry·Sabine WillemsDaniel Merk

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Methods Mentioned

BETA
transgenic

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