Vitamin D and Calcimimetics in Cardiovascular Disease

Seminars in Nephrology
Kenneth LimRavi Thadhani

Abstract

Cardiovascular disease has earned its place as one of the leading noncommunicable diseases that has become a modern-day global epidemic. The increasing incidence and prevalence of chronic kidney disease (CKD) has added to this enormous burden, given that CKD is now recognized as an established risk factor for accelerated cardiovascular disease. In fact, cardiovascular disease remains the leading cause of death in the CKD population, with significant prognostic implications. Alterations in vitamin D levels as renal function declines has been linked invariably to the development of cardiovascular disease beyond a mere epiphenomenon, and has become an important focus in recent years in our search for new therapies. Another compound, cinacalcet, which belongs to the calcimimetic class of agents, also has taken center stage over the past few years as a potential cardiovasculoprotective agent. However, given limited well-designed randomized trials to inform us, our clinical practice for the management of cardiovascular disease in CKD has not been adequately refined. This article considers the biological mechanisms, regulation, and current experimental, clinical, and trial data available to help guide the therapeutic use of vitamin D ...Continue Reading

Citations

Mar 13, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·David A BushinskyGeoffrey A Block
Apr 5, 2019·The Journal of Clinical Endocrinology and Metabolism·Thomas HiemstraJoAnn E Manson
Sep 25, 2019·International Journal of Molecular Sciences·Kenneth LimIrene Chong
Dec 30, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anique D Ter BraakeJoost G J Hoenderop
Jan 5, 2021·Molecular Biology Reports·Anubha SinghChanderdeep Tandon
Jan 9, 2021·Clinical Science·Jakob VoelklCarsten A Wagner

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