Vitamin D and calcium supplementation, skeletal muscle strength and serum testosterone in young healthy adult males: Randomized control trial

Clinical Endocrinology
Soma SahaUpinderpal Singh

Abstract

Cholecalciferol and/or calcium supplementation might increase skeletal muscle strength and serum testosterone in young adult males. We performed a randomized control trial assessing the effect of cholecalciferol/calcium on skeletal muscle strength and serum testosterone in vitamin D deficient young males. Two-by-two factorial RCT. Two-hundred and twenty-eight young males were block-randomized to (i) double-placebo, (ii) calcium/placebo, (iii) cholecalciferol/placebo and (iv) cholecalciferol/calcium. Doses for cholecalciferol were 60 000 IU/wk for 8 weeks followed by 60 000 IU/fortnightly, and doses for elemental calcium were 500 mg/twice daily for 6 months. A total of 180 subjects completed the study protocol. Their  ean age, body mass index and baseline 25(OH)D were 20.2 ± 2.2 years, 23.0 ± 3.6 kg/m2 and 21.5 ± 9.5 nmol/L, respectively. Handgrip (primary outcome), pinch-grip strength, distance walked in 6 minutes, dyspnoea-score, quality of life by Short Form 36, serum 25(OH)D, 1,25(OH)2 D, iPTH, total testosterone and free androgen index (FAI). After intervention, mean serum 25(OH)D was >75.0 nmol/L in cholecalciferol groups. However, the handgrip strength (29.7 ± 4.4, 29.3 ± 4.6, 30.6 ± 5.0 and 28.8 ± 4.3 kg, P = .28) was co...Continue Reading

References

Jul 1, 1985·American Journal of Epidemiology·W C WillettF E Speizer
Sep 1, 1993·The Journal of Pediatrics·J D SargentR Z Klein
Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·A VermeulenJ M Kaufman
Aug 2, 2000·The American Journal of Clinical Nutrition·R GoswamiN Kochupillai
Sep 6, 2002·European Journal of Endocrinology·Ravinder GoswamiNarayana Kochupillai
Feb 6, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Heike A BischoffMartin Conzelmann
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Johan SvartbergElizabeth Barrett-Connor
Aug 6, 2003·Medicine and Science in Sports and Exercise·Cora L CraigPekka Oja
Apr 12, 2007·The Journal of Clinical Endocrinology and Metabolism·N BinkleyM K Drezner
Jan 12, 2010·The Journal of Clinical Endocrinology and Metabolism·Mara J HorwitzAndrew F Stewart
Dec 15, 2010·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S PilzA Zittermann
Jan 10, 2012·Clinical Endocrinology·Katharina NimptschEdward Giovannucci
Mar 21, 2012·Annals of Internal Medicine·J Christopher GallagherLynette Smith
May 21, 2013·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R JordeJ Svartberg
Jul 1, 2014·The Journal of Clinical Endocrinology and Metabolism·Natalie E CusanoJohn P Bilezikian
Aug 20, 2014·Current Opinion in Clinical Nutrition and Metabolic Care·Pamela R von Hurst, Kathryn L Beck
Oct 4, 2014·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·E K McCarthy, M Kiely
Jan 6, 2015·Clinical Endocrinology·Annemieke C HeijboerPaul Lips
May 23, 2015·BioMed Research International·Matthieu HalfonDaniel Teta
Nov 5, 2015·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Matthew A WyonYiannis Koutedakis
Jul 6, 2016·Journal of Strength and Conditioning Research·Chien-Ming ChiangSuzy Weems
Jan 12, 2017·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Onder CanguvenAbdullah Al Naimi
May 19, 2017·Reviews in Endocrine & Metabolic Disorders·Michael F Holick

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Citations

Jan 5, 2019·The Journal of Clinical Endocrinology and Metabolism·Soma Saha, Ravinder Goswami
May 16, 2019·Clinical Endocrinology·Pramila DharmshaktuRavinder Goswami
Nov 5, 2019·The Medical Journal of Australia·Ian R Reid, Mark J Bolland
Mar 4, 2020·Nutrients·Patrizia D'Amelio, Luca Quacquarelli
Jan 16, 2020·The Indian Journal of Medical Research·Ravinder Goswami, Abilash Nair
Sep 15, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Adam W ByersWayne W Campbell
Feb 11, 2021·Klinicheskaia laboratornaia diagnostika·S V BulgakovaN O Zakharova
Feb 23, 2021·The Journal of Clinical Endocrinology and Metabolism·Soma SahaRavinder Goswami
Aug 19, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lise Sofie BislevLars Rejnmark

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