Vitamin D and Disease Severity in Multiple Sclerosis-Baseline Data From the Randomized Controlled Trial (EVIDIMS)

Frontiers in Neurology
Priscilla Bäcker-KoduahFriedemann Paul

Abstract

Objective: To investigate the associations between hypovitaminosis D and disease activity in a cohort of relapsing remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS) patients. Methods: In 51 RRMS and 2 CIS patients on stable interferon-β-1b (IFN-β-1b) treatment recruited to the EVIDIMS study (Efficacy of Vitamin D Supplementation in Multiple Sclerosis (NCT01440062) baseline serum vitamin D levels were evaluated. Patients were dichotomized based on the definition of vitamin D deficiency which is reflected by a < 30 vs. ≥ 30 ng/ml level of 25-hydroxyvitamin D (25(OH)D). Possible associations between vitamin D deficiency and both clinical and MRI features of the disease were analyzed. Results: Median (25, 75% quartiles, Q) 25(OH)D level was 18 ng/ml (12, 24). Forty eight out of 53 (91%) patients had 25(OH)D levels < 30 ng/ml (p < 0.001). Patients with 25(OH)D ≥ 30 ng/ml had lower median (25, 75% Q) T2-weighted lesion counts [25 (24, 33)] compared to patients with 25(OH)D < 30 ng/ml [60 (36, 84), p = 0.03; adjusted for age, gender and disease duration: p < 0.001]. Expanded disability status scale (EDSS) score was negatively associated with serum 25(OH)D levels in a multiple linear regression, including age, ...Continue Reading

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Citations

Aug 25, 2020·Annals of Clinical and Translational Neurology·Priscilla Bäcker-KoduahAlexander Ulrich Brandt
Apr 22, 2021·BMC Neurology·Zhila MaghbooliMohammad Ali Sahraian
Jun 8, 2021·Journal of Neuroimmunology·Masaaki NiinoSeiji Kikuchi

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Clinical Trials Mentioned

NCT01440062

Software Mentioned

SOLAR
SIENA FMRIB
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GRAPPA
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ITK
SOSTANA
SAS

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